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PSMC4 [nucleoplasm]
Stable Identifier
R-HSA-174315
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit 6B, MIP224, MB67 interacting protein, TAT-binding protein-7, TBP-7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
19S regulatory particle [nucleoplasm] (Homo sapiens)
19S RP base [nucleoplasm] (Homo sapiens)
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43686 PSMC4
Gene Names
PSMC4, MIP224, TBP7
Chain
chain:1-418
Reference Genes
BioGPS Gene:5704 PSMC4
COSMIC (genes):PSMC4 PSMC4
CTD Gene:5704 PSMC4
dbSNP Gene:5704 PSMC4
ENSEMBL:ENSG00000013275 PSMC4
ENSEMBL_homo_sapiens_GENE:ENSG00000013275.8 PSMC4
ENSEMBL_homo_sapiens_GENE:ENSG00000281221.3 PSMC4
HGNC:9551 PSMC4
KEGG Gene (Homo sapiens):5704 PSMC4
Monarch:5704 PSMC4
NCBI Gene:5704 PSMC4
OMIM:602707 PSMC4
UCSC:P43686 PSMC4
Reference Transcript
RefSeq:NM_006503.3 PSMC4
RefSeq:NM_153001.2 PSMC4
Other Identifiers
11718881_a_at
11718882_x_at
16862145
201252_PM_at
201252_at
32848_at
3833292
3833293
3833294
3833295
3833296
3833297
3833298
3833300
3833301
3833304
3833306
3833308
3833310
3833311
3833312
5704
8028756
A_14_P113810
A_24_P91310
GE80314
GO:0000166
GO:0000502
GO:0001824
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006508
GO:0008540
GO:0016020
GO:0016787
GO:0016887
GO:0022624
GO:0030163
GO:0036402
GO:0043161
GO:0043226
GO:0048856
GO:0140657
GO:1901800
HMNXSV003008946
HMNXSV003013766
ILMN_1687887
ILMN_2287888
ILMN_2395389
PH_hs_0012274
TC19000557.hg
g5729990_3p_s_at
Participates
as a component of
PSMC4:PSMC5 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMC4 [cytosol]
Inferred To
Rpt3 [nucleoplasm]
(Drosophila melanogaster)
PSMC4 [nucleoplasm]
(Bos taurus)
PSMC4 [nucleoplasm]
(Caenorhabditis elegans)
PSMC4 [nucleoplasm]
(Canis familiaris)
PSMC4 [nucleoplasm]
(Dictyostelium discoideum)
PSMC4 [nucleoplasm]
(Mus musculus)
PSMC4 [nucleoplasm]
(Rattus norvegicus)
PSMC4 [nucleoplasm]
(Sus scrofa)
psmc4 [nucleoplasm]
(Danio rerio)
psmc4 [nucleoplasm]
(Xenopus tropicalis)
Ghost homologue of PSMC4 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_006494.1
,
NP_694546.1
OpenTargets
ENSG00000013275
GeneCards
P43686
HPA
ENSG00000013275-PSMC4
Ensembl
ENSP00000413869
,
ENSP00000485851
,
ENST00000455878
,
ENSG00000013275
,
ENSG00000281221
,
ENSP00000487367
,
ENST00000629691
,
ENSP00000157812
,
ENST00000157812
,
ENST00000630857
PRO
P43686
Pharos - Targets
P43686
PDB
6MSB
,
5VHJ
,
6MSD
,
5VFT
,
5VHI
,
5T0I
,
5VFS
,
5VFP
,
5GJR
,
7QXN
,
5LN3
,
7QXP
,
5VHS
,
7W37
,
5T0G
,
6MSK
,
7W3K
,
5VHO
,
7W3M
,
6MSJ
,
5VHP
,
2DVW
,
7W3I
,
6MSE
,
7W3H
,
7W3J
,
7QYB
,
7W3F
,
7QYA
,
7W3G
,
7W3B
,
5VHH
,
5VFU
,
7W3C
,
5GJQ
,
5VFR
,
5T0J
,
7QXW
,
5VHF
,
7W3A
,
7QXX
,
7QY7
,
7W38
,
8CVT
,
5VFQ
,
5T0H
,
7W39
,
7QXU
,
5T0C
,
5VHR
,
5M32
,
5VGZ
,
5VHQ
,
6MSH
,
6WJN
,
5VHM
,
6WJD
,
6MSG
,
5L4G
,
5VHN
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75832 PSMD10
1
PSMD10 [cytosol]
(R-HSA-68788)
0.964
28
UniProt:P62195 PSMC5
2
PSMC5 [nucleoplasm]
(R-HSA-174312)
PSMC5 [cytosol]
(R-HSA-68780)
0.938
20
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.825
9
UniProt:P62191 PSMC1
2
PSMC1 [nucleoplasm]
(R-HSA-174338)
PSMC1 [cytosol]
(R-HSA-68768)
0.813
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.788
7
UniProt:P35998 PSMC2
5
PSMC2 [secretory granule lumen]
(R-HSA-6800994)
PSMC2 [extracellular region]
(R-HSA-6806472)
PSMC2 [ficolin-1-rich granule lumen]
(R-HSA-6800421)
PSMC2 [nucleoplasm]
(R-HSA-174332)
PSMC2 [cytosol]
(R-HSA-68771)
0.744
6
UniProt:P51665 PSMD7
5
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [cytosol]
(R-HSA-68806)
0.744
6
UniProt:Q99460 PSMD1
4
PSMD1 [extracellular region]
(R-HSA-6806194)
PSMD1 [azurophil granule lumen]
(R-HSA-6798741)
PSMD1 [nucleoplasm]
(R-HSA-174348)
PSMD1 [cytosol]
(R-HSA-68786)
0.669
4
UniProt:Q15008 PSMD6
5
PSMD6 [secretory granule lumen]
(R-HSA-6801036)
PSMD6 [extracellular region]
(R-HSA-6806486)
PSMD6 [ficolin-1-rich granule lumen]
(R-HSA-6800440)
PSMD6 [nucleoplasm]
(R-HSA-174316)
PSMD6 [cytosol]
(R-HSA-68804)
0.669
4
UniProt:P55036 PSMD4
1
PSMD4 [cytosol]
(R-HSA-68800)
0.669
4
UniProt:Q13200 PSMD2
5
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [cytosol]
(R-HSA-68796)
0.669
5
UniProt:Q9UNM6 PSMD13
5
PSMD13 [secretory granule lumen]
(R-HSA-6800983)
PSMD13 [extracellular region]
(R-HSA-6806469)
PSMD13 [ficolin-1-rich granule lumen]
(R-HSA-6800413)
PSMD13 [nucleoplasm]
(R-HSA-174326)
PSMD13 [cytosol]
(R-HSA-68794)
0.669
6
UniProt:O00231 PSMD11
5
PSMD11 [secretory granule lumen]
(R-HSA-6800943)
PSMD11 [extracellular region]
(R-HSA-6806441)
PSMD11 [ficolin-1-rich granule lumen]
(R-HSA-6800436)
PSMD11 [nucleoplasm]
(R-HSA-174327)
PSMD11 [cytosol]
(R-HSA-68790)
0.669
4
UniProt:Q9BRP4 PAAF1
1
PAAF1 [cytosol]
(R-HSA-9907973)
0.669
4
UniProt:P17980 PSMC3
5
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [cytosol]
(R-HSA-68774)
0.669
5
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
DLST [mitochondrial matrix]
(R-HSA-6792574)
0.666
5
UniProt:Q16186 ADRM1
2
ADRM1 [nucleoplasm]
(R-HSA-9918361)
ADRM1 [cytosol]
(R-HSA-5665939)
0.643
5
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.643
3
UniProt:Q9Z2X2
1
Psmd10 [cytosol]
(R-MMU-68788)
0.618
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
21
UniProt:Q8TDX7 NEK7
2
p-S195-NEK7 [cytosol]
(R-HSA-2984246)
NEK7 [cytosol]
(R-HSA-2530599)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:Q99436 PSMB7
7
PSMB7(1-43) [cytosol]
(R-HSA-9908129)
pro-PSMB7 [cytosol]
(R-HSA-9908145)
PSMB7 [secretory granule lumen]
(R-HSA-6803279)
PSMB7 [extracellular region]
(R-HSA-6806449)
PSMB7 [ficolin-1-rich granule lumen]
(R-HSA-6803312)
PSMB7 [nucleoplasm]
(R-HSA-174331)
PSMB7 [cytosol]
(R-HSA-68759)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:O00232 PSMD12
5
PSMD12 [secretory granule lumen]
(R-HSA-6800934)
PSMD12 [extracellular region]
(R-HSA-6806480)
PSMD12 [ficolin-1-rich granule lumen]
(R-HSA-6800416)
PSMD12 [nucleoplasm]
(R-HSA-174339)
PSMD12 [cytosol]
(R-HSA-68792)
0.527
4
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.527
2
UniProt:P49721 PSMB2
2
PSMB2 [nucleoplasm]
(R-HSA-174335)
PSMB2 [cytosol]
(R-HSA-68744)
0.527
3
UniProt:O43242 PSMD3
5
PSMD3 [secretory granule lumen]
(R-HSA-6800873)
PSMD3 [extracellular region]
(R-HSA-6806443)
PSMD3 [ficolin-1-rich granule lumen]
(R-HSA-6800408)
PSMD3 [nucleoplasm]
(R-HSA-174328)
PSMD3 [cytosol]
(R-HSA-68798)
0.527
4
UniProt:Q16401 PSMD5
1
PSMD5 [cytosol]
(R-HSA-68802)
0.527
3
UniProt:P48556 PSMD8
2
PSMD8 [nucleoplasm]
(R-HSA-174318)
PSMD8 [cytosol]
(R-HSA-68808)
0.527
2
UniProt:O00233 PSMD9
1
PSMD9 [cytosol]
(R-HSA-68810)
0.527
2
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