Reactome | PSMD6 [nucleoplasm]

PSMD6 [nucleoplasm]

Stable Identifier

R-HSA-174316

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit S10, p42A, Proteasome regulatory particle subunit p44S10

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        19S regulatory particle [nucleoplasm] (Homo sapiens)
        
        19S RP lid [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 2 [nucleoplasm] (Homo sapiens)
        
        19S RP lid particle 3 [nucleoplasm] (Homo sapiens)
        
        PSMD6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15008 PSMD6

Gene Names

PSMD6, KIAA0107, PFAAP4

Chain

initiator methionine:, chain:2-389

Reference Genes

BioGPS Gene:9861 PSMD6

COSMIC (genes):PSMD6 PSMD6

CTD Gene:9861 PSMD6

dbSNP Gene:9861 PSMD6

ENSEMBL:ENSG00000163636 PSMD6

ENSEMBL_homo_sapiens_GENE:ENSG00000163636.11 PSMD6

HGNC:9564 PSMD6

KEGG Gene (Homo sapiens):9861 PSMD6

Monarch:9861 PSMD6

NCBI Gene:9861 PSMD6

OMIM:617857 PSMD6

UCSC:Q15008 PSMD6

Reference Transcript

Other Identifiers

11731415_a_at

11746510_x_at

16955771

202753_3p_at

202753_PM_at

202753_at

2679865

2679866

2679867

2679869

2679872

2679876

2679877

2679878

2679879

2679881

2679884

2679885

2679886

2679887

34680_s_at

8088535

9861

A_23_P109928

D14663_at

GE54973

GO:0000502

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0022624

GO:0030163

GO:0031410

GO:0034774

GO:0043161

GO:0043226

GO:1904813

HMNXSV003039793

ILMN_1779633

ILMN_2155998

PH_hs_0016942

TC03001522.hg

g7661913_3p_at

g7661913_3p_s_at

Participates

as a component of

19S RP lid particle 3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD6 [secretory granule lumen]

PSMD6 [extracellular region]

PSMD6 [ficolin-1-rich granule lumen]

PSMD6 [cytosol]

Inferred To

PSMD6 [nucleoplasm] (Bos taurus)

PSMD6 [nucleoplasm] (Canis familiaris)

PSMD6 [nucleoplasm] (Gallus gallus)

PSMD6 [nucleoplasm] (Sus scrofa)

psmd6 [nucleoplasm] (Danio rerio)

psmd6 [nucleoplasm] (Xenopus tropicalis)

rpn-7 [nucleoplasm] (Caenorhabditis elegans)

Rpn7 [nucleoplasm] (Drosophila melanogaster)

Psmd6 [nucleoplasm] (Mus musculus)

Psmd6 [nucleoplasm] (Rattus norvegicus)

psmD6 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001258710.1, NP_055629.1, NP_001258709.1, NP_001258708.1

OpenTargets

ENSG00000163636

GeneCards

Q15008

HPA

ENSG00000163636-PSMD6

Ensembl

ENSP00000418695, ENST00000482510, ENSP00000295901, ENSG00000163636, ENSP00000377952, ENST00000394431, ENSP00000419227, ENST00000492933, ENST00000295901

PRO

Q15008

Pharos - Targets

Q15008

PDB

5T0J, 5VFR, 6WJN, 7QXN, 5T0I, 5VFP, 7QXX, 6MSB, 8CVT, 7QY7, 5VFT, 7W3I, 7W38, 5L4K, 7QXU, 5GJQ, 7QXW, 6MSG, 5VHH, 5VFU, 7W3G, 7W3H, 6MSD, 7W37, 7W3K, 5GJR, 7W3M, 7W3C, 5T0G, 7W3F, 5VGZ, 7W3J, 5VFQ, 7QYA, 7W3A, 5T0H, 7QYB, 5VHF, 5VFS, 7W39, 5T0C, 5LN3, 6MSH, 5VHI, 5M32, 7QXP, 6MSK, 7W3B, 5VHS, 6MSJ, 6WJD

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51665 PSMD7	5	PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [cytosol] (R-HSA-68806)	0.802	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	6
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.758	5
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.744	6
UniProt:P49720 PSMB3	2	PSMB3 [nucleoplasm] (R-HSA-174341) PSMB3 [cytosol] (R-HSA-68747)	0.744	5
UniProt:P62195 PSMC5	2	PSMC5 [nucleoplasm] (R-HSA-174312) PSMC5 [cytosol] (R-HSA-68780)	0.744	6
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.744	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	7
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.744	4
UniProt:Q99436 PSMB7	7	PSMB7(1-43) [cytosol] (R-HSA-9908129) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [cytosol] (R-HSA-68759)	0.669	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.669	3
UniProt:Q13200 PSMD2	5	PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [cytosol] (R-HSA-68796)	0.669	4
UniProt:O43242 PSMD3	5	PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [cytosol] (R-HSA-68798)	0.669	5
UniProt:Q9UNM6 PSMD13	5	PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [cytosol] (R-HSA-68794)	0.669	6
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.667	3
UniProt:O00231 PSMD11	5	PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [cytosol] (R-HSA-68790)	0.667	4
UniProt:Q16186 ADRM1	2	ADRM1 [nucleoplasm] (R-HSA-9918361) ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.589	2
UniProt:P28074 PSMB5	4	PSMB5(1-59) [cytosol] (R-HSA-9908134) pro-PSMB5 [cytosol] (R-HSA-9908135) PSMB5 [nucleoplasm] (R-HSA-174344) PSMB5 [cytosol] (R-HSA-68753)	0.564	2
UniProt:P60900 PSMA6	2	PSMA6 [nucleoplasm] (R-HSA-174314) PSMA6 [cytosol] (R-HSA-68734)	0.564	2
UniProt:P35998 PSMC2	5	PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [cytosol] (R-HSA-68771)	0.564	3
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.564	2
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.564	2
UniProt:P25788 PSMA3	2	PSMA3 [nucleoplasm] (R-HSA-174323) PSMA3 [cytosol] (R-HSA-68728)	0.564	2
UniProt:P25787 PSMA2	5	PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [cytosol] (R-HSA-68726)	0.564	3
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.564	3
UniProt:Q9UMX0-2 UBQLN1			0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q9H8Y8 GORASP2	2	GORASP2 [Golgi membrane] (R-HSA-2422385) p-T222,T225-GORASP2 [Golgi membrane] (R-HSA-2422965)	0.556	5
UniProt:Q96FZ5 CKLF7			0.556	3
UniProt:P20133	2	RABGGTB [cytosol] (R-SCE-8870419) RABGGTB [plasma membrane] (R-SCE-6801098)	0.556	3
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:Q53HC0 CCD92			0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P49721 PSMB2	2	PSMB2 [nucleoplasm] (R-HSA-174335) PSMB2 [cytosol] (R-HSA-68744)	0.527	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	3
UniProt:P28065 PSMB9	3	PSMB9(1-20) [cytosol] (R-HSA-9908132) PSMB9 [cytosol] (R-HSA-68765) pro-PSMB9 [cytosol] (R-HSA-9908136)	0.527	4
UniProt:Q96G75 RMND5B	1	RMND5B [cytosol] (R-HSA-9861550)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	8

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