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PSMD10 [nucleoplasm]
Stable Identifier
R-HSA-174322
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit p28, Gankyrin
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD10 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75832 PSMD10
Gene Names
PSMD10
Chain
chain:1-226
Reference Genes
BioGPS Gene:5716 PSMD10
COSMIC (genes):PSMD10 PSMD10
CTD Gene:5716 PSMD10
dbSNP Gene:5716 PSMD10
ENSEMBL:ENSG00000101843 PSMD10
ENSEMBL_homo_sapiens_GENE:ENSG00000101843.19 PSMD10
HGNC:9555 PSMD10
KEGG Gene (Homo sapiens):5716 PSMD10
Monarch:5716 PSMD10
NCBI Gene:5716 PSMD10
OMIM:300880 PSMD10
UCSC:O75832 PSMD10
Reference Transcript
RefSeq:NM_170750.2 PSMD10
RefSeq:NM_002814.3 PSMD10
Other Identifiers
11717585_a_at
11736946_a_at
1554577_PM_a_at
1554577_a_at
17113184
219485_PM_s_at
219485_s_at
2656796
37350_at
4017520
4017521
4017522
4017523
4017526
4017527
4017528
4017530
4017532
5716
64301_r_at
8174379
A_23_P258570
A_33_P3335621
GE62902
GO:0000122
GO:0000502
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0007005
GO:0007253
GO:0008092
GO:0008134
GO:0008540
GO:0012501
GO:0023052
GO:0030163
GO:0030307
GO:0030674
GO:0031398
GO:0032088
GO:0032436
GO:0036211
GO:0043005
GO:0043066
GO:0043226
GO:0043409
GO:0043518
GO:0044325
GO:0045111
GO:0045737
GO:0060090
GO:0061629
GO:0065003
GO:0070682
GO:0072659
GO:0090201
HMNXSV003030287
Hs2.7756.2.S1_3p_s_at
ILMN_1776102
ILMN_2281128
ILMN_2383435
PH_hs_0030183
TC0X001266.hg
TC0X002181.hg
g4506216_3p_a_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMD10 [cytosol]
Inferred To
psmD10 [nucleoplasm]
(Dictyostelium discoideum)
Psmd10 [nucleoplasm]
(Mus musculus)
Psmd10 [nucleoplasm]
(Rattus norvegicus)
PSMD10 [nucleoplasm]
(Canis familiaris)
PSMD10 [nucleoplasm]
(Danio rerio)
PSMD10 [nucleoplasm]
(Sus scrofa)
Ghost homologue of PSMD10 [nucleoplasm]
(Bos taurus)
Ghost homologue of PSMD10 [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of PSMD10 [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of PSMD10 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_736606.1
,
NP_002805.1
OpenTargets
ENSG00000101843
GeneCards
O75832
HPA
ENSG00000101843-PSMD10
Ensembl
ENSG00000101843
,
ENSP00000354906
,
ENST00000361815
,
ENSP00000217958
,
ENST00000217958
PRO
O75832
Pharos - Targets
O75832
PDB
5VHR
,
5VHJ
,
7VXW
,
7VO6
,
7VXV
,
1QYM
,
5VHQ
,
5VHI
,
1UOH
,
7VY7
,
5VHM
,
7VY4
,
5VHO
,
5VHF
,
4NIK
,
5VHN
,
1TR4
,
5VHP
,
5VHH
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
2
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.564
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.564
2
UniProt:Q12849 GRSF1
2
GRSF1 [mitochondrial matrix]
(R-HSA-9837006)
GRSF1 [cytosol]
(R-HSA-192689)
0.558
4
UniProt:P0DMV8 HSPA1A
4
HSPA1A [nucleoplasm]
(R-HSA-6792605)
HSPA1A [cytosol]
(R-HSA-6792602)
HSPA1A [extracellular region]
(R-HSA-6805872)
HSPA1A [ficolin-1-rich granule lumen]
(R-HSA-6801496)
0.544
2
UniProt:Q02750 MAP2K1
20
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 L42_K57del [cytosol]
(R-HSA-9652026)
0.462
2
UniProt:O94760 DDAH1
1
DDAH1 [cytosol]
(R-HSA-6783970)
0.462
3
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