Reactome | PSMA1 [nucleoplasm]

PSMA1 [nucleoplasm]

Stable Identifier

R-HSA-174333

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P25786 PSMA1

Gene Names

PSMA1, HC2, NU, PROS30, PSC2

Chain

chain:1-263

Reference Genes

BioGPS Gene:5682 PSMA1

COSMIC (genes):PSMA1 PSMA1

CTD Gene:5682 PSMA1

dbSNP Gene:5682 PSMA1

ENSEMBL:ENSG00000129084 PSMA1

HGNC:9530 PSMA1

KEGG Gene (Homo sapiens):5682 PSMA1

Monarch:5682 PSMA1

NCBI Gene:5682 PSMA1

OMIM:602854 PSMA1

UCSC:P25786 PSMA1

Reference Transcript

Other Identifiers

0005700440

0005700487

11718582_a_at

16736049

201676_x_at

210759_s_at

211746_x_at

3363980

3363981

3363982

3363983

3363986

3363988

3363993

3363994

3363995

3363997

3364000

3364001

3364002

3364006

3364027

3364028

3364031

33765

37646

38371_at

3982763

43891

4R3O

4R67

5682

5A0Q

5GJQ

5GJR

5L4G

5LE5

5LEX

5LEY

5LEZ

5LF0

5LF1

5LF3

5LF4

5LF6

5LF7

5LN3

5M32

5T0C

5T0G

5T0H

5T0I

5T0J

5VFO

5VFP

5VFQ

5VFR

5VFS

5VFT

5VFU

6AVO

6MSB

6MSD

6MSE

6MSG

6MSH

6MSJ

6MSK

7946728

A_23_P150286

AAA92734

AAH02577

AAH05932

AAH08472

AAH09576

AAH15105

AAH15356

AAH22372

AAP35293

AK290765

BAA00656

BAF83454

BC002577

BC005932

BC008472

BC009576

BC015105

BC015356

BC022372

BT006647

CAA43961

CAB033765

CCDS31431

CCDS7816

CH471064

D00759

EAW68479

ENSG00000129084

ENSP00000379676

ENSP00000414359

ENST00000396394

ENST00000396394.6

ENST00000418988

ENST00000418988.2

EntrezGene:5682

EntrezGene:PSMA1

F5GX11

g190446_3p_s_at

GE59873

GO:0000165

GO:0000209

GO:0000278

GO:0000502

GO:0001530

GO:0002223

GO:0002376

GO:0002479

GO:0002862

GO:0003674

GO:0003723

GO:0004175

GO:0004298

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0005844

GO:0005856

GO:0006464

GO:0006508

GO:0006511

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008233

GO:0008289

GO:0009056

GO:0009058

GO:0010498

GO:0010499

GO:0010972

GO:0016579

GO:0016787

GO:0019773

GO:0030154

GO:0031145

GO:0031146

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0038061

GO:0038095

GO:0043161

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0048856

GO:0050852

GO:0051603

GO:0055085

GO:0060071

GO:0061418

GO:0070062

GO:0070498

GO:0090090

GO:0090263

GO:1901990

GO:1902036

HGNC:9530

HPA037646

HPA043891

ILMN_1691809

ILMN_1760542

IPR000426

IPR001353

IPR023332

IPR029055

IPR035144

M64992

M64992_at

MIM:602854

NM_002786

NM_148976

NP_002777

NP_683877

PF00227

PF10584

PH_hs_0004700

PH_hs_0035476

PSMA1

PSMA1-201

PSMA1-202

SM00948

TC11003474.hg

UPI0000000DEF

UPI000002B1AC

X61969

Participant Of

hasComponent

26S proteasome [nucleoplasm]

Other forms of this molecule

PSMA1 [cytosol]

Inferred To

Prosalpha6 [nucleoplasm] (Drosophila melanogaster)

psmA1 [nucleoplasm] (Dictyostelium discoideum)

Psma1 [nucleoplasm] (Rattus norvegicus)

PSMA1 [nucleoplasm] (Bos taurus)

PSMA1 [nucleoplasm] (Canis familiaris)

PSMA1 [nucleoplasm] (Sus scrofa)

pas-6 [nucleoplasm] (Caenorhabditis elegans)

psma1 [nucleoplasm] (Danio rerio)

psma1 [nucleoplasm] (Xenopus tropicalis)

Proteasome subunit alpha type-1 [nucleoplasm] (Mus musculus)

Cross References

RefSeq

NP_002777.1, NP_683877.1

OpenTargets

ENSG00000129084

GeneCards

P25786

HPA

ENSG00000129084-PSMA1

Ensembl

ENST00000396394, ENSP00000414359, ENSG00000129084, ENST00000418988, ENSP00000379676

PRO

P25786

PDB

6MSG, 5LE5, 5M32, 5LEY, 5T0H, 5VFT, 5GJQ, 5VFP, 5T0C, 6MSH, 5LEZ, 5LF4, 6AVO, 6R70, 5T0I, 6MSB, 5LF0, 5VFU, 5GJR, 5VFQ, 6E5B, 6MSJ, 6MSD, 5LF6, 4R67, 5T0G, 5VFR, 5A0Q, 5LF1, 5LF7, 6REY, 6MSE, 5LN3, 6MSK, 6RGQ, 5LEX, 5T0J, 4R3O, 5L4G, 5LF3, 5VFS, 5VFO

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.742	5
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.718	6
UniProt:Q99081 TCF12	1	TCF12 [nucleoplasm] (R-HSA-445670)	0.666	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [plasma membrane] (R-HSA-936955) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.589	2
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	6
UniProt:Q9GZV8 PRDM14	1	PRDM14 [nucleoplasm] (R-HSA-1112608)	0.556	3
UniProt:P28482 MAPK1	8	MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.556	3
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:Q8IY31 IFT20	3	IFT20 [Golgi membrane] (R-HSA-5617625) IFT20 [cilium] (R-HSA-5617624) IFT20 [ciliary tip] (R-HSA-5625355)	0.556	3
UniProt:Q13077 TRAF1	3	TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1 [cytosol] (R-HSA-5634163) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:O75525 KHDRBS3	2	p-Y-KHDRSB3 [nucleoplasm] (R-HSA-8849035) KHDRSB3 [nucleoplasm] (R-HSA-8849040)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:Q96GX9 APIP	1	APIP [cytosol] (R-HSA-1237171)	0.556	3
UniProt:O15160 POLR1C	2	POLR1C [nucleoplasm] (R-HSA-63498) POLR1C [cytosol] (R-HSA-1964454)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.527	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.462	2
UniProt:P04578 env	7	Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2