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PSMA1 [nucleoplasm]
Stable Identifier
R-HSA-174333
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25786 PSMA1
Gene Names
PSMA1, HC2, NU, PROS30, PSC2
Chain
chain:1-263
Reference Genes
BioGPS Gene:5682 PSMA1
COSMIC (genes):PSMA1 PSMA1
CTD Gene:5682 PSMA1
dbSNP Gene:5682 PSMA1
ENSEMBL:ENSG00000129084 PSMA1
HGNC:9530 PSMA1
KEGG Gene (Homo sapiens):5682 PSMA1
Monarch:5682 PSMA1
NCBI Gene:5682 PSMA1
OMIM:602854 PSMA1
UCSC:P25786 PSMA1
Reference Transcript
RefSeq:NM_002786.3 PSMA1
RefSeq:NM_148976.2 PSMA1
Other Identifiers
0005700440
0005700487
11718582_a_at
16736049
201676_x_at
210759_s_at
211746_x_at
3363980
3363981
3363982
3363983
3363986
3363988
3363993
3363994
3363995
3363997
3364000
3364001
3364002
3364006
3364027
3364028
3364031
38371_at
3982763
5682
7946728
A_23_P150286
GE59873
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0001530
GO:0002223
GO:0002376
GO:0002479
GO:0002862
GO:0003674
GO:0003723
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005839
GO:0005844
GO:0005856
GO:0006464
GO:0006508
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0008289
GO:0009056
GO:0009058
GO:0010498
GO:0010499
GO:0010972
GO:0016579
GO:0016787
GO:0019773
GO:0030154
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
ILMN_1691809
ILMN_1760542
M64992_at
PH_hs_0004700
PH_hs_0035476
TC11003474.hg
g190446_3p_s_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMA1 [cytosol]
Inferred To
Prosalpha6 [nucleoplasm] (Drosophila melanogaster)
psmA1 [nucleoplasm] (Dictyostelium discoideum)
Psma1 [nucleoplasm] (Rattus norvegicus)
PSMA1 [nucleoplasm] (Canis familiaris)
PSMA1 [nucleoplasm] (Sus scrofa)
PSMA1 [nucleoplasm] (Xenopus tropicalis)
pas-6 [nucleoplasm] (Caenorhabditis elegans)
psma1 [nucleoplasm] (Danio rerio)
Proteasome subunit alpha type-1 [nucleoplasm] (Mus musculus)
Cross References
RefSeq
NP_683877.1
,
NP_002777.1
OpenTargets
ENSG00000129084
GeneCards
P25786
HPA
ENSG00000129084-PSMA1
Ensembl
ENSP00000414359
,
ENST00000396394
,
ENST00000418988
,
ENSG00000129084
,
ENSP00000379676
PRO
P25786
PDB
5VFO
,
6MSE
,
5LF6
,
6MSG
,
5GJQ
,
5LN3
,
5T0J
,
5M32
,
6MSB
,
5T0I
,
5VFT
,
6R70
,
5VFU
,
6KWY
,
5LF3
,
6E5B
,
5LF4
,
6AVO
,
6MSD
,
5VFR
,
5LEY
,
6MSK
,
4R67
,
5LF0
,
5LEZ
,
4R3O
,
5VFS
,
5L4G
,
5LF1
,
5LE5
,
5T0H
,
5LF7
,
5VFP
,
5T0C
,
5GJR
,
6RGQ
,
6XMJ
,
6REY
,
6MSH
,
5LEX
,
6MSJ
,
5A0Q
,
5VFQ
,
5T0G
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.742
5
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.718
6
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.666
4
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.589
2
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:O75525 KHDRBS3
2
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
0.556
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.556
3
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.556
3
UniProt:P28482 MAPK1
18
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
PICK1 [plasma membrane]
(R-HSA-416989)
0.556
3
UniProt:Q8IY31 IFT20
3
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.556
3
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.556
6
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q96GX9 APIP
1
APIP [cytosol]
(R-HSA-1237171)
0.556
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:Q9NW13 RBM28
1
RBM28 [nucleoplasm]
(R-HSA-6791192)
0.462
2
UniProt:P04578 env
7
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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