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PSMA1 [nucleoplasm]
Stable Identifier
R-HSA-174333
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 1 , Proteasome component C2, Macropain subunit C2, Multicatalytic endopeptidase complex subunit C2, Proteasome nu chain, 30 kDa prosomal protein, PROS-30
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25786 PSMA1
Gene Names
PSMA1, HC2, NU, PROS30, PSC2
Chain
chain:1-263
Reference Genes
BioGPS Gene:5682 PSMA1
COSMIC (genes):PSMA1 PSMA1
CTD Gene:5682 PSMA1
dbSNP Gene:5682 PSMA1
ENSEMBL:ENSG00000129084 PSMA1
ENSEMBL_homo_sapiens_GENE:ENSG00000129084.18 PSMA1
HGNC:9530 PSMA1
KEGG Gene (Homo sapiens):5682 PSMA1
Monarch:5682 PSMA1
NCBI Gene:5682 PSMA1
OMIM:602854 PSMA1
UCSC:P25786 PSMA1
Reference Transcript
RefSeq:NM_148976.2 PSMA1
RefSeq:NM_002786.3 PSMA1
Other Identifiers
11718582_a_at
16736049
201676_PM_x_at
201676_x_at
210759_PM_s_at
210759_s_at
211746_PM_x_at
211746_x_at
3363980
3363981
3363982
3363983
3363986
3363988
3363993
3363994
3363995
3363997
3364000
3364001
3364002
3364006
3364027
3364028
3364031
38371_at
3982763
5682
7946728
A_23_P150286
GE59873
GO:0000502
GO:0001530
GO:0002376
GO:0002862
GO:0003723
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005839
GO:0005844
GO:0005856
GO:0006511
GO:0006954
GO:0008289
GO:0019773
GO:0030163
GO:0043161
GO:0043226
GO:0051603
GO:0070062
HMNXSV003028073
HMNXSV003043291
ILMN_1691809
ILMN_1760542
M64992_at
PH_hs_0004700
PH_hs_0035476
TC11003474.hg
g190446_3p_s_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMA1 [cytosol]
Inferred To
Prosalpha6 [nucleoplasm]
(Drosophila melanogaster)
psmA1 [nucleoplasm]
(Dictyostelium discoideum)
Psma1 [nucleoplasm]
(Rattus norvegicus)
zgc:92726 [nucleoplasm]
(Danio rerio)
PSMA1 [nucleoplasm]
(Bos taurus)
PSMA1 [nucleoplasm]
(Canis familiaris)
PSMA1 [nucleoplasm]
(Gallus gallus)
PSMA1 [nucleoplasm]
(Sus scrofa)
pas-6 [nucleoplasm]
(Caenorhabditis elegans)
Proteasome subunit alpha type-1 [nucleoplasm]
(Mus musculus)
Cross References
RefSeq
NP_683877.1
,
NP_002777.1
OpenTargets
ENSG00000129084
GeneCards
P25786
HPA
ENSG00000129084-PSMA1
Ensembl
ENST00000418988
,
ENSP00000379676
,
ENST00000396394
,
ENSG00000129084
,
ENSP00000414359
PRO
P25786
Pharos - Targets
P25786
PDB
5T0G
,
5LEX
,
7QXW
,
5GJR
,
7V5M
,
5LF1
,
7W3M
,
5A0Q
,
7LXV
,
5LF0
,
4R3O
,
5L4G
,
7NAP
,
6REY
,
7W3G
,
7W3J
,
8CVT
,
5T0H
,
5VFS
,
5VFT
,
5T0I
,
7W3F
,
7QXX
,
7B12
,
6MSD
,
7W3A
,
5VFO
,
7W3I
,
7NAQ
,
5VFP
,
6E5B
,
6AVO
,
5LF7
,
5LF6
,
7PG9
,
6MSG
,
6R70
,
7W3B
,
6XMJ
,
6WJD
,
7QXU
,
6MSE
,
8CXB
,
5VFR
,
6MSH
,
7NHT
,
7W38
,
6WJN
,
5LEZ
,
7NAN
,
7W3C
,
5LEY
,
8CVS
,
7QY7
,
6RGQ
,
7QXP
,
4R67
,
7W39
,
5LF4
,
5LF3
,
7QXN
,
7NAO
,
6MSJ
,
5LE5
,
7W3K
,
8CVR
,
5LN3
,
6MSB
,
6MSK
,
6KWY
,
5VFU
,
5T0J
,
7QYB
,
7W37
,
5GJQ
,
5M32
,
7AWE
,
7W3H
,
7V5G
,
5VFQ
,
5T0C
,
7QYA
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40692 MLH1
3
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 [nucleoplasm]
(R-HSA-912495)
0.742
5
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:P55072 VCP
8
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [cytosol]
(R-HSA-1181251)
0.718
6
UniProt:Q99081 TCF12
1
TCF12 [nucleoplasm]
(R-HSA-445670)
0.666
4
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.652
3
UniProt:Q9Y4K3 TRAF6
8
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
TRAF6 [endosome membrane]
(R-HSA-450272)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
0.589
2
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.556
6
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q719H9 KCTD1
1
KCTD1 [nucleoplasm]
(R-HSA-8864339)
0.556
3
UniProt:Q9HD42 CHMP1A
1
CHMP1A [cytosol]
(R-HSA-917721)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:O75525 KHDRBS3
2
KHDRSB3 [nucleoplasm]
(R-HSA-8849040)
p-Y-KHDRSB3 [nucleoplasm]
(R-HSA-8849035)
0.556
3
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.556
3
UniProt:Q96GX9 APIP
1
APIP [cytosol]
(R-HSA-1237171)
0.556
3
UniProt:P57764 GSDMD
13
GSDMD [specific granule lumen]
(R-HSA-6801468)
GSDMD [ficolin-1-rich granule lumen]
(R-HSA-6801498)
GSDMD [extracellular region]
(R-HSA-6801576)
GSDMD [tertiary granule lumen]
(R-HSA-6801501)
GSDMD(88-484) [cytosol]
(R-HSA-9686133)
GSDMD(1-87) [cytosol]
(R-HSA-9686099)
GSDMD(1-275) [cytosol]
(R-HSA-9647641)
GSDMD [cytosol]
(R-HSA-6801577)
GSDMD(276-484) [cytosol]
(R-HSA-9647672)
GSDMD(269-484) [cytosol]
(R-HSA-9710116)
GSDMD(1-268) [cytosol]
(R-HSA-9710104)
S-(2-succinyl)-C191-GSDMD [cytosol]
(R-HSA-9716198)
dithiocarb-C191-GSDMD(1-275) [cytosol]
(R-HSA-9693317)
0.556
3
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.556
3
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.556
3
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.556
3
UniProt:Q8IY31 IFT20
3
IFT20 [cilium]
(R-HSA-5617624)
IFT20 [Golgi membrane]
(R-HSA-5617625)
IFT20 [ciliary tip]
(R-HSA-5625355)
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
ENV [viral envelope]
(R-HIV-173439)
0.462
2
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