Reactome | PSMB8 [nucleoplasm]

PSMB8 [nucleoplasm]

Stable Identifier

R-HSA-174336

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 8, Proteasome subunit beta type 8 precursor , Proteasome component C13, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMB8 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28062 PSMB8

Gene Names

PSMB8, LMP7, PSMB5i, RING10, Y2

Chain

propeptide:1-72, chain:73-276

Reference Genes

BioGPS Gene:5696 PSMB8

COSMIC (genes):PSMB8 PSMB8

CTD Gene:5696 PSMB8

dbSNP Gene:5696 PSMB8

ENSEMBL:ENSG00000204264 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000204264.12 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000206298.8 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000226201.6 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000230034.8 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000230669.6 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000231631.6 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000235715.6 PSMB8

ENSEMBL_homo_sapiens_GENE:ENSG00000236443.6 PSMB8

HGNC:9545 PSMB8

KEGG Gene (Homo sapiens):5696 PSMB8

Monarch:5696 PSMB8

NCBI Gene:5696 PSMB8

OMIM:177046 PSMB8

UCSC:P28062 PSMB8

Reference Transcript

Other Identifiers

11715665_a_at

11747961_a_at

17017965

17027130

17029774

17032462

17034777

17037257

17039963

17042473

209040_PM_s_at

209040_s_at

2950200

2950201

2950203

2950204

2950205

2950206

2950208

2950210

2950212

2950213

41184_s_at

5696

8125500

8178855

8180049

A_23_P250629

GE59826

GO:0000502

GO:0002376

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005839

GO:0006508

GO:0008233

GO:0010498

GO:0016787

GO:0019774

GO:0019882

GO:0030154

GO:0030163

GO:0043226

GO:0045444

GO:0051603

GO:0052548

GO:0070062

GO:0140096

GO:1990111

HMNXSV003041566

ILMN_1747195

ILMN_1767006

ILMN_2284794

ILMN_2390299

PH_hs_0010658

PH_hs_0035651

TC06001573.hg

TC6_apd_hap1000104.hg

TC6_cox_hap2000198.hg

TC6_dbb_hap3000184.hg

TC6_mann_hap4000166.hg

TC6_mcf_hap5000173.hg

TC6_qbl_hap6000186.hg

TC6_ssto_hap7000168.hg

Z14982_rna1_at

g596139_3p_a_at

Participates

as an output of

Expression of IFN-induced genes (Homo sapiens)

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB8 [cytosol]

Inferred To

PSMB8 [nucleoplasm] (Bos taurus)

PSMB8 [nucleoplasm] (Canis familiaris)

psmb8 [nucleoplasm] (Danio rerio)

Ghost homologue of PSMB8 [nucleoplasm] (Gallus gallus)

Ghost homologue of PSMB8 [nucleoplasm] (Sus scrofa)

Proteasome subunit beta type-8 [nucleoplasm] (Mus musculus)

pbs-5 [nucleoplasm] (Caenorhabditis elegans)

psmB5 [nucleoplasm] (Dictyostelium discoideum)

Psmb8 [nucleoplasm] (Rattus norvegicus)

Prosbeta5R2 [nucleoplasm] (Drosophila melanogaster)

Prosbeta5 [nucleoplasm] (Drosophila melanogaster)

Prosbeta5R1 [nucleoplasm] (Drosophila melanogaster)

Homologues of PSMB8 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_004150.1, NP_683720.2

ZINC - World Drugs

PSB8_HUMAN

Guide to Pharmacology - Targets

2408

OpenTargets

ENSG00000204264

ZINC - FDA approved

PSB8_HUMAN

ZINC - Substances

PSB8_HUMAN

ZINC target

P28062

PRO

P28062

PDB

5LTT, 5L5J, 5L5Q, 5L5E, 5L5R, 5L5D, 5L5S, 7B12, 7AWE, 6AVO, 5L5F, 5M2B, 5L5H, 5L5I, 5L5V, 6E5B, 5L5B, 5L5T, 5L5O, 5L5U, 5L5A, 5L5P

ZINC - Investigational

PSB8_HUMAN

GeneCards

P28062

HPA

ENSG00000204264-PSMB8

Ensembl

ENSG00000230669, ENSG00000226201, ENSG00000231631, ENSG00000235715, ENST00000374882, ENSG00000230034, ENSG00000206298, ENSG00000236443, ENSP00000406797, ENST00000383238, ENSP00000364016, ENST00000383236, ENST00000455660, ENSP00000372725, ENSP00000402406, ENST00000436627, ENST00000457261, ENSP00000414770, ENSP00000394155, ENSP00000372723, ENSP00000392693, ENSP00000364015, ENST00000435978, ENST00000441960, ENST00000452573, ENSP00000404585, ENST00000429645, ENST00000416134, ENSG00000204264, ENSP00000412618, ENST00000438442, ENSP00000397057, ENSP00000414731, ENSP00000408825, ENST00000421445, ENSP00000407539, ENST00000374881, ENST00000416564

Pharos - Targets

P28062

ZINC - Predictions - Purchasable

PSB8_HUMAN

Orphanet

19820

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27958-PRO_0000037573			0.581	4