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PSMB8 [nucleoplasm]
Stable Identifier
R-HSA-174336
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 8, Proteasome subunit beta type 8 precursor , Proteasome component C13, Macropain subunit C13, Multicatalytic endopeptidase complex subunit C13
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Expression of IFN-induced genes (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28062 PSMB8
Gene Names
PSMB8, LMP7, PSMB5i, RING10, Y2
Chain
propeptide:1-72, chain:73-276
Reference Genes
BioGPS Gene:5696 PSMB8
COSMIC (genes):PSMB8 PSMB8
CTD Gene:5696 PSMB8
dbSNP Gene:5696 PSMB8
ENSEMBL:ENSG00000204264 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000204264.12 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000206298.8 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000226201.6 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000230034.8 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000230669.6 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000231631.6 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000235715.6 PSMB8
ENSEMBL_homo_sapiens_GENE:ENSG00000236443.6 PSMB8
HGNC:9545 PSMB8
KEGG Gene (Homo sapiens):5696 PSMB8
Monarch:5696 PSMB8
NCBI Gene:5696 PSMB8
OMIM:177046 PSMB8
UCSC:P28062 PSMB8
Reference Transcript
RefSeq:NM_004159.4 PSMB8
RefSeq:NM_148919.3 PSMB8
Other Identifiers
11715665_a_at
11747961_a_at
17017965
17027130
17029774
17032462
17034777
17037257
17039963
17042473
209040_PM_s_at
209040_s_at
2950200
2950201
2950203
2950204
2950205
2950206
2950208
2950210
2950212
2950213
41184_s_at
5696
8125500
8178855
8180049
A_23_P250629
GE59826
GO:0000502
GO:0002376
GO:0003824
GO:0004175
GO:0004298
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006508
GO:0008233
GO:0010498
GO:0016787
GO:0019774
GO:0019882
GO:0030154
GO:0030163
GO:0043226
GO:0045444
GO:0051603
GO:0052548
GO:0070062
GO:0140096
GO:1990111
HMNXSV003041566
ILMN_1747195
ILMN_1767006
ILMN_2284794
ILMN_2390299
PH_hs_0010658
PH_hs_0035651
TC06001573.hg
TC6_apd_hap1000104.hg
TC6_cox_hap2000198.hg
TC6_dbb_hap3000184.hg
TC6_mann_hap4000166.hg
TC6_mcf_hap5000173.hg
TC6_qbl_hap6000186.hg
TC6_ssto_hap7000168.hg
Z14982_rna1_at
g596139_3p_a_at
Participates
as an output of
Expression of IFN-induced genes (Homo sapiens)
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB8 [cytosol]
Inferred To
PSMB8 [nucleoplasm]
(Bos taurus)
PSMB8 [nucleoplasm]
(Canis familiaris)
psmb8 [nucleoplasm]
(Danio rerio)
Ghost homologue of PSMB8 [nucleoplasm]
(Gallus gallus)
Ghost homologue of PSMB8 [nucleoplasm]
(Sus scrofa)
Proteasome subunit beta type-8 [nucleoplasm]
(Mus musculus)
pbs-5 [nucleoplasm]
(Caenorhabditis elegans)
psmB5 [nucleoplasm]
(Dictyostelium discoideum)
Psmb8 [nucleoplasm]
(Rattus norvegicus)
Prosbeta5R2 [nucleoplasm]
(Drosophila melanogaster)
Prosbeta5 [nucleoplasm]
(Drosophila melanogaster)
Prosbeta5R1 [nucleoplasm]
(Drosophila melanogaster)
Homologues of PSMB8 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_004150.1
,
NP_683720.2
ZINC - World Drugs
PSB8_HUMAN
Guide to Pharmacology - Targets
2408
OpenTargets
ENSG00000204264
ZINC - FDA approved
PSB8_HUMAN
ZINC - Substances
PSB8_HUMAN
ZINC target
P28062
PRO
P28062
PDB
5LTT
,
5L5J
,
5L5Q
,
5L5E
,
5L5R
,
5L5D
,
5L5S
,
7B12
,
7AWE
,
6AVO
,
5L5F
,
5M2B
,
5L5H
,
5L5I
,
5L5V
,
6E5B
,
5L5B
,
5L5T
,
5L5O
,
5L5U
,
5L5A
,
5L5P
ZINC - Investigational
PSB8_HUMAN
GeneCards
P28062
HPA
ENSG00000204264-PSMB8
Ensembl
ENSG00000230669
,
ENSG00000226201
,
ENSG00000231631
,
ENSG00000235715
,
ENST00000374882
,
ENSG00000230034
,
ENSG00000206298
,
ENSG00000236443
,
ENSP00000406797
,
ENST00000383238
,
ENSP00000364016
,
ENST00000383236
,
ENST00000455660
,
ENSP00000372725
,
ENSP00000402406
,
ENST00000436627
,
ENST00000457261
,
ENSP00000414770
,
ENSP00000394155
,
ENSP00000372723
,
ENSP00000392693
,
ENSP00000364015
,
ENST00000435978
,
ENST00000441960
,
ENST00000452573
,
ENSP00000404585
,
ENST00000429645
,
ENST00000416134
,
ENSG00000204264
,
ENSP00000412618
,
ENST00000438442
,
ENSP00000397057
,
ENSP00000414731
,
ENSP00000408825
,
ENST00000421445
,
ENSP00000407539
,
ENST00000374881
,
ENST00000416564
Pharos - Targets
P28062
ZINC - Predictions - Purchasable
PSB8_HUMAN
Orphanet
19820
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27958-PRO_0000037573
0.581
4
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