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PSMC1 [nucleoplasm]
Stable Identifier
R-HSA-174338
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit 4, P26s4
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62191 PSMC1
Gene Names
PSMC1
Chain
initiator methionine:1, chain:2-440
Reference Genes
BioGPS Gene:5700 PSMC1
COSMIC (genes):PSMC1 PSMC1
CTD Gene:5700 PSMC1
dbSNP Gene:5700 PSMC1
ENSEMBL:ENSG00000100764 PSMC1
HGNC:9547 PSMC1
KEGG Gene (Homo sapiens):5700 PSMC1
Monarch:5700 PSMC1
NCBI Gene:5700 PSMC1
OMIM:602706 PSMC1
UCSC:P62191 PSMC1
Reference Transcript
RefSeq:NM_002802.2 PSMC1
RefSeq:NM_001330212.1 PSMC1
RefSeq:XM_017021470.1 PSMC1
Other Identifiers
0002760129
11716545_x_at
11748303_x_at
16787409
204219_3p_s_at
204219_s_at
2471205
2471210
2628584
2628585
2628586
2628587
2628588
2628589
2628590
2628591
2628592
2628593
2703461
2822886
2822887
2822888
2869838
3026199
3406993
3406995
3406997
3407003
3407007
3548281
3548286
3548287
3548288
3548290
3548291
3548292
3548295
3548299
3548301
3548303
3548307
3548308
3548310
3548312
3548314
3548316
3548317
3548318
3548320
3548322
3548324
5700
688_at
7976189
8080923
A_24_P347488
A_32_P57870
A_32_P9700
GE61348
GO:0000165
GO:0000166
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0003723
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006457
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008219
GO:0008540
GO:0009056
GO:0009058
GO:0010972
GO:0016020
GO:0016579
GO:0016787
GO:0016887
GO:0017025
GO:0022624
GO:0030154
GO:0030163
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0036402
GO:0038061
GO:0038095
GO:0043161
GO:0043167
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0070498
GO:0090090
GO:0090263
GO:1901215
GO:1901800
GO:1901990
GO:1902036
ILMN_1710406
ILMN_1721659
ILMN_1736353
ILMN_3295075
L02426_at
PH_hs_0032853
TC14000552.hg
g4506206_3p_a_at
g4506206_3p_s_at
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMC1 [cytosol]
Inferred To
rpt-2 [nucleoplasm] (Caenorhabditis elegans)
psmC1 [nucleoplasm] (Dictyostelium discoideum)
Psmc1 [nucleoplasm] (Mus musculus)
Psmc1 [nucleoplasm] (Rattus norvegicus)
psmc1a [nucleoplasm] (Danio rerio)
Rpt2 [nucleoplasm] (Drosophila melanogaster)
PSMC1 [nucleoplasm] (Canis familiaris)
PSMC1 [nucleoplasm] (Sus scrofa)
PSMC1 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001317141.1
,
XP_016876959.1
,
NP_002793.2
OpenTargets
ENSG00000100764
HPA
ENSG00000100764-PSMC1
GeneCards
P62191
Ensembl
ENST00000261303
,
ENST00000543772
,
ENSP00000261303
,
ENSG00000100764
,
ENSP00000445147
PRO
P62191
PDB
5T0H
,
6MSH
,
6MSJ
,
5VHR
,
5VFP
,
5VHS
,
5VHJ
,
5VHI
,
5T0I
,
5L4G
,
6MSK
,
5VHN
,
5VHM
,
5VFR
,
5VFQ
,
5T0J
,
6MSB
,
5M32
,
5VGZ
,
5VHP
,
5VHO
,
5VFT
,
5T0C
,
5VFS
,
5LN3
,
5GJQ
,
6MSD
,
5T0G
,
6MSG
,
5VHH
,
5VHQ
,
5GJR
,
5VFU
,
5VHF
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:P00441 SOD1
5
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [extracellular region]
(R-HSA-350705)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.666
5
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.643
4
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
0.589
2
UniProt:P54578 USP14
1
USP14 [cytosol]
(R-HSA-5689541)
0.564
2
UniProt:O00487 PSMD14
5
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
3
UniProt:P55072 VCP
8
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [extracellular region]
(R-HSA-6806191)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [cytosol]
(R-HSA-1181251)
0.556
3
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
2
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
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