Reactome | PSMC1 [nucleoplasm]

PSMC1 [nucleoplasm]

Stable Identifier

R-HSA-174338

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 4, P26s4

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P62191 PSMC1

Gene Names

PSMC1

Chain

initiator methionine:1, chain:2-440

Reference Genes

BioGPS Gene:5700 PSMC1

COSMIC (genes):PSMC1 PSMC1

CTD Gene:5700 PSMC1

dbSNP Gene:5700 PSMC1

ENSEMBL:ENSG00000100764.14 PSMC1

HGNC:9547 PSMC1

KEGG Gene (Homo sapiens):5700 PSMC1

Monarch:5700 PSMC1

NCBI Gene:5700 PSMC1

OMIM:602706 PSMC1

UCSC:P62191 PSMC1

Reference Transcript

Other Identifiers

0002760129

11716545_x_at

11748303_x_at

16787409

204219_3p_s_at

204219_PM_s_at

204219_s_at

2471205

2471210

2628584

2628585

2628586

2628587

2628588

2628589

2628590

2628591

2628592

2628593

2703461

2822886

2822887

2822888

2869838

3026199

3406993

3406995

3406997

3407003

3407007

3548281

3548286

3548287

3548288

3548290

3548291

3548292

3548295

3548299

3548301

3548303

3548307

3548308

3548310

3548312

3548314

3548316

3548317

3548318

3548320

3548322

3548324

5700

688_at

7976189

8080923

A_24_P347488

A_32_P57870

A_32_P9700

GE61348

GO:0000166

GO:0000502

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008134

GO:0008150

GO:0008540

GO:0016020

GO:0016887

GO:0017025

GO:0022624

GO:0030163

GO:0032991

GO:0036402

GO:0043161

GO:0043167

GO:0043226

GO:0140657

GO:1901215

GO:1901800

HMNXSV003052549

ILMN_1710406

ILMN_1721659

ILMN_1736353

ILMN_3295075

L02426_at

PH_hs_0032853

TC14000552.hg

g4506206_3p_a_at

g4506206_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC1 [cytosol]

Inferred To

PSMC1 [nucleoplasm] (Bos taurus)

PSMC1 [nucleoplasm] (Caenorhabditis elegans)

PSMC1 [nucleoplasm] (Canis familiaris)

PSMC1 [nucleoplasm] (Danio rerio)

PSMC1 [nucleoplasm] (Dictyostelium discoideum)

PSMC1 [nucleoplasm] (Drosophila melanogaster)

PSMC1 [nucleoplasm] (Gallus gallus)

PSMC1 [nucleoplasm] (Mus musculus)

PSMC1 [nucleoplasm] (Rattus norvegicus)

PSMC1 [nucleoplasm] (Sus scrofa)

psmc1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001317141.1, XP_016876959.1, NP_002793.2

OpenTargets

ENSG00000100764

HPA

ENSG00000100764-PSMC1

GeneCards

P62191

Ensembl

ENSP00000445147, ENSP00000261303, ENST00000543772, ENSG00000100764, ENST00000261303

PRO

P62191

Pharos - Targets

P62191

PDB

5VHM, 6WJN, 5VGZ, 5VFR, 5L4G, 5VHJ, 6MSK, 5T0J, 5VFQ, 5GJR, 5T0I, 5VHS, 5VHI, 5VFP, 6MSJ, 6MSH, 6WJD, 5VHH, 5T0H, 5LN3, 5T0G, 5M32, 6MSG, 5VHR, 5GJQ, 5VHQ, 5VHF, 6MSD, 5VFU, 5T0C, 5VFT, 5VHP, 6MSB, 5VHO, 5VHN, 5VFS

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.825	7
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082)	0.666	5
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227)	0.589	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.564	2
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	3
UniProt:P37840 SNCA	4	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [secretory granule lumen] (R-HSA-6801039) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.527	2
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [cytosol] (R-HSA-9020974) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2

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