Reactome | PSMC1 [nucleoplasm]

PSMC1 [nucleoplasm]

Stable Identifier

R-HSA-174338

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 4, P26s4

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P62191 PSMC1

Gene Names

PSMC1

Chain

initiator methionine:1, chain:2-440

Reference Genes

BioGPS Gene:5700 PSMC1

COSMIC (genes):PSMC1 PSMC1

CTD Gene:5700 PSMC1

dbSNP Gene:5700 PSMC1

ENSEMBL:ENSG00000100764 PSMC1

HGNC:9547 PSMC1

KEGG Gene (Homo sapiens):5700 PSMC1

Monarch:5700 PSMC1

NCBI Gene:5700 PSMC1

OMIM:602706 PSMC1

UCSC:P62191 PSMC1

Reference Transcript

Other Identifiers

0002760129

11716545_x_at

11748303_x_at

16787409

204219_3p_s_at

204219_s_at

2471205

2471210

2628584

2628585

2628586

2628587

2628588

2628589

2628590

2628591

2628592

2628593

2703461

2822886

2822887

2822888

2869838

3026199

3406993

3406995

3406997

3407003

3407007

3548281

3548286

3548287

3548288

3548290

3548291

3548292

3548295

3548299

3548301

3548303

3548307

3548308

3548310

3548312

3548314

3548316

3548317

3548318

3548320

3548322

3548324

5700

688_at

7976189

8080923

A_24_P347488

A_32_P57870

A_32_P9700

GE61348

GO:0000165

GO:0000166

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0003723

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006457

GO:0006464

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008134

GO:0008150

GO:0008219

GO:0008540

GO:0009056

GO:0009058

GO:0010972

GO:0016020

GO:0016579

GO:0016787

GO:0016887

GO:0017025

GO:0022624

GO:0030154

GO:0030163

GO:0031145

GO:0031146

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0036402

GO:0038061

GO:0038095

GO:0043161

GO:0043167

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0070498

GO:0090090

GO:0090263

GO:1901215

GO:1901800

GO:1901990

GO:1902036

ILMN_1710406

ILMN_1721659

ILMN_1736353

ILMN_3295075

L02426_at

PH_hs_0032853

TC14000552.hg

g4506206_3p_a_at

g4506206_3p_s_at

Participant Of

hasComponent

26S proteasome [nucleoplasm]

Other forms of this molecule

PSMC1 [cytosol]

Inferred To

rpt-2 [nucleoplasm] (Caenorhabditis elegans)

psmC1 [nucleoplasm] (Dictyostelium discoideum)

Psmc1 [nucleoplasm] (Mus musculus)

Psmc1 [nucleoplasm] (Rattus norvegicus)

psmc1a [nucleoplasm] (Danio rerio)

Rpt2 [nucleoplasm] (Drosophila melanogaster)

PSMC1 [nucleoplasm] (Canis familiaris)

PSMC1 [nucleoplasm] (Sus scrofa)

PSMC1 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001317141.1, XP_016876959.1, NP_002793.2

OpenTargets

ENSG00000100764

HPA

ENSG00000100764-PSMC1

GeneCards

P62191

Ensembl

ENST00000261303, ENST00000543772, ENSP00000261303, ENSG00000100764, ENSP00000445147

PRO

P62191

PDB

5T0H, 6MSH, 6MSJ, 5VHR, 5VFP, 5VHS, 5VHJ, 5VHI, 5T0I, 5L4G, 6MSK, 5VHN, 5VHM, 5VFR, 5VFQ, 5T0J, 6MSB, 5M32, 5VGZ, 5VHP, 5VHO, 5VFT, 5T0C, 5VFS, 5LN3, 5GJQ, 6MSD, 5T0G, 6MSG, 5VHH, 5VHQ, 5GJR, 5VFU, 5VHF

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:P00441 SOD1	5	2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.666	5
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845)	0.589	2
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.564	2
UniProt:O00487 PSMD14	5	PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	3
UniProt:P55072 VCP	8	VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [nucleoplasm] (R-HSA-5643745) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [secretory granule lumen] (R-HSA-6801039) VCP [cytosol] (R-HSA-1181251)	0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	2
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2