Reactome | PSMD12 [nucleoplasm]

PSMD12 [nucleoplasm]

Stable Identifier

R-HSA-174339

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit p55

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMD12 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O00232 PSMD12

Gene Names

PSMD12

Chain

initiator methionine:1, chain:2-456

Reference Genes

BioGPS Gene:5718 PSMD12

COSMIC (genes):PSMD12 PSMD12

CTD Gene:5718 PSMD12

dbSNP Gene:5718 PSMD12

ENSEMBL:ENSG00000197170.10 PSMD12

HGNC:9557 PSMD12

KEGG Gene (Homo sapiens):5718 PSMD12

Monarch:5718 PSMD12

NCBI Gene:5718 PSMD12

OMIM:604450 PSMD12

UCSC:O00232 PSMD12

Reference Transcript

Other Identifiers

0004730292

11732779_a_at

11739251_a_at

11758041_s_at

11759291_s_at

1192_at

16848032

202352_PM_s_at

202352_s_at

202353_PM_s_at

202353_s_at

2682615

2682617

2682620

3768104

3768105

3768106

3768107

3768108

3768109

3768110

3768111

3768112

3768113

3768114

3768117

3768119

3768120

3768121

3768122

3768123

3768126

3768128

3768136

3768137

3768138

5718

8017810

AB003103_at

A_23_P112613

A_23_P77876

A_32_P12639

GE53110

GO:0000502

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008150

GO:0008541

GO:0016020

GO:0022624

GO:0030163

GO:0031410

GO:0031595

GO:0032991

GO:0034774

GO:0043161

GO:0043226

GO:0070062

GO:1904813

HMNXSV003048354

Hs.4295.0.S1_3p_a_at

ILMN_1691428

ILMN_2368971

PH_hs_0000479

TC17001813.hg

g4506220_3p_a_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMD12 [secretory granule lumen]

PSMD12 [extracellular region]

PSMD12 [ficolin-1-rich granule lumen]

PSMD12 [cytosol]

Inferred To

psmD12 [nucleoplasm] (Dictyostelium discoideum)

PSMD12 [nucleoplasm] (Bos taurus)

PSMD12 [nucleoplasm] (Canis familiaris)

PSMD12 [nucleoplasm] (Gallus gallus)

PSMD12 [nucleoplasm] (Sus scrofa)

PSMD12 [nucleoplasm] (Xenopus tropicalis)

Rpn5 [nucleoplasm] (Drosophila melanogaster)

fc34f08 [nucleoplasm] (Danio rerio)

rpn-5 [nucleoplasm] (Caenorhabditis elegans)

Psmd12 [nucleoplasm] (Mus musculus)

Psmd12 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001303270.1, NP_002807.1, NP_777360.1

OpenTargets

ENSG00000197170

GeneCards

O00232

HPA

ENSG00000197170-PSMD12

Ensembl

ENSP00000348442, ENSG00000197170, ENST00000357146, ENST00000356126, ENSP00000349667

PRO

O00232

Pharos - Targets

O00232

Orphanet

27829

PDB

5VGZ, 5VFR, 5VFQ, 5T0J, 6MSJ, 6MSK, 6WJN, 5M32, 5LN3, 5GJQ, 5VFT, 5VFS, 5VHF, 5T0C, 5T0G, 6MSD, 5GJR, 5VHH, 5VFU, 6MSB, 6MSE, 5VHI, 5VFP, 5T0I, 6WJD, 5T0H, 6MSG, 6MSH, 5L4K, 5VHS

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.669	3
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.667	3
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227)	0.589	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3