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PSMD12 [nucleoplasm]
Stable Identifier
R-HSA-174339
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit p55
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD12 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00232 PSMD12
Gene Names
PSMD12
Chain
initiator methionine:1, chain:2-456
Reference Genes
BioGPS Gene:5718 PSMD12
COSMIC (genes):PSMD12 PSMD12
CTD Gene:5718 PSMD12
dbSNP Gene:5718 PSMD12
ENSEMBL:ENSG00000197170 PSMD12
HGNC:9557 PSMD12
KEGG Gene (Homo sapiens):5718 PSMD12
Monarch:5718 PSMD12
NCBI Gene:5718 PSMD12
OMIM:604450 PSMD12
UCSC:O00232 PSMD12
Reference Transcript
RefSeq:NM_001316341.1 PSMD12
RefSeq:NM_002816.4 PSMD12
RefSeq:NM_174871.3 PSMD12
Other Identifiers
0004730292
11732779_a_at
11739251_a_at
11758041_s_at
11759291_s_at
1192_at
16848032
202352_s_at
202353_s_at
23119
2682615
2682617
2682620
3768104
3768105
3768106
3768107
3768108
3768109
3768110
3768111
3768112
3768113
3768114
3768117
3768119
3768120
3768121
3768122
3768123
3768126
3768128
3768136
3768137
3768138
5718
5GJQ
5GJR
5L4K
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHS
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
8017810
A0A0S2Z489
A_23_P112613
A_23_P77876
A_32_P12639
AAH19062
AAH65826
AB003103
AB003103_at
AC110921
AK091198
AK222679
ALQ33746
BAA19749
BAD96399
BAG52303
BC019062
BC065826
CCDS11669
CCDS11670
CH471099
EAW89026
EAW89028
ENSG00000197170
ENSP00000348442
ENSP00000349667
ENST00000356126
ENST00000356126.7
ENST00000357146
ENST00000357146.4
EntrezGene:5718
EntrezGene:PSMD12
g4506220_3p_a_at
GE53110
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005838
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008541
GO:0009056
GO:0009058
GO:0010972
GO:0016020
GO:0016192
GO:0016579
GO:0022624
GO:0030154
GO:0031145
GO:0031146
GO:0031410
GO:0031595
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
HGNC:9557
HPA023119
Hs.4295.0.S1_3p_a_at
ILMN_1691428
ILMN_2368971
IPR000717
IPR035297
IPR036388
IPR036390
IPR040134
IPR040896
J3KSK1
J3KTJ5
KU178288
MIM:604450
MIM:617516
NM_001316341
NM_002816
NM_174871
NP_001303270
NP_002807
NP_777360
PF01399
PF18098
PH_hs_0000479
PSMD12
PSMD12-201
PSMD12-202
SM00088
SM00753
TC17001813.hg
UPI0000132792
UPI0000167F8C
XM_024450842
XM_024450843
XP_024306610
XP_024306611
XR_001752571
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMD12 [secretory granule lumen]
PSMD12 [extracellular region]
PSMD12 [ficolin-1-rich granule lumen]
PSMD12 [cytosol]
Inferred To
PSMD12 [nucleoplasm] (Bos taurus)
PSMD12 [nucleoplasm] (Caenorhabditis elegans)
PSMD12 [nucleoplasm] (Canis familiaris)
PSMD12 [nucleoplasm] (Danio rerio)
PSMD12 [nucleoplasm] (Dictyostelium discoideum)
PSMD12 [nucleoplasm] (Drosophila melanogaster)
PSMD12 [nucleoplasm] (Mus musculus)
PSMD12 [nucleoplasm] (Rattus norvegicus)
PSMD12 [nucleoplasm] (Sus scrofa)
PSMD12 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_002807.1
,
NP_777360.1
,
NP_001303270.1
OpenTargets
ENSG00000197170
GeneCards
O00232
PRO
O00232
Orphanet
27829
PDB
5VFU
,
6MSK
,
5T0J
,
6MSJ
,
5VFP
,
5T0C
,
5VHH
,
6MSB
,
5VHF
,
5VFQ
,
5L4K
,
5T0G
,
5VFS
,
5VFR
,
6MSE
,
5GJQ
,
6MSD
,
5T0H
,
5VHI
,
5M32
,
5VGZ
,
5VFT
,
5LN3
,
5T0I
,
5GJR
,
6MSH
,
5VHS
,
6MSG
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00487 PSMD14
5
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [cytosol]
(R-HSA-68722)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
0.669
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:Q9Y4K3 TRAF6
8
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [plasma membrane]
(R-HSA-936955)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.589
2
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
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