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PSMB3 [nucleoplasm]
Stable Identifier
R-HSA-174341
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 3 , Proteasome theta chain, Proteasome chain 13, Proteasome component C10-II
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49720 PSMB3
Gene Names
PSMB3
Chain
initiator methionine:, chain:2-205
Reference Genes
BioGPS Gene:5691 PSMB3
CTD Gene:5691 PSMB3
dbSNP Gene:5691 PSMB3
ENSEMBL:ENSG00000275903 PSMB3
ENSEMBL:ENSG00000277791 PSMB3
ENSEMBL_homo_sapiens_GENE:ENSG00000275903.2 PSMB3
ENSEMBL_homo_sapiens_GENE:ENSG00000277791.5 PSMB3
HGNC:9540 PSMB3
KEGG Gene (Homo sapiens):5691 PSMB3
Monarch:5691 PSMB3
NCBI Gene:5691 PSMB3
OMIM:602176 PSMB3
UCSC:P49720 PSMB3
Reference Transcript
RefSeq:NM_002795.3 PSMB3
Other Identifiers
11715732_at
1309_at
16833698
201400_PM_at
201400_at
3719963
3719964
3719965
3719967
3719968
3719971
3719972
3719973
3719974
5691
8006812
A_23_P100576
A_33_P3234899
D26598_at
GE57141
GO:0000502
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0019774
GO:0030163
GO:0043161
GO:0043226
GO:0051603
GO:0070062
HMNXSV003043158
ILMN_1748651
TC17000466.hg
g4506196_3p_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB3 [cytosol]
Inferred To
wu:fb11d10 [nucleoplasm]
(Danio rerio)
Prosbeta3 [nucleoplasm]
(Drosophila melanogaster)
Psmb3 [nucleoplasm]
(Rattus norvegicus)
psmB3 [nucleoplasm]
(Dictyostelium discoideum)
PSMB3 [nucleoplasm]
(Bos taurus)
PSMB3 [nucleoplasm]
(Canis familiaris)
PSMB3 [nucleoplasm]
(Gallus gallus)
PSMB3 [nucleoplasm]
(Sus scrofa)
Proteasome subunit beta type-3 [nucleoplasm]
(Mus musculus)
pbs-3 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002786.2
OpenTargets
ENSG00000277791
HPA
ENSG00000277791-PSMB3
GeneCards
P49720
Ensembl
ENST00000619426
,
ENSG00000277791
,
ENSG00000275903
,
ENSP00000483956
,
ENST00000619951
,
ENSP00000483688
PRO
P49720
Pharos - Targets
P49720
PDB
7QXU
,
6RGQ
,
5LE5
,
7NAO
,
6MSH
,
7V5M
,
5LF3
,
6MSJ
,
7QYB
,
7W39
,
5LF4
,
8CVT
,
5T0J
,
7QXP
,
6WJD
,
7QXW
,
7W3B
,
6MSK
,
7QXX
,
7NAQ
,
7AWE
,
7NAP
,
7PG9
,
5VFS
,
5VFR
,
5GJQ
,
7W3A
,
7QY7
,
6WJN
,
5LEX
,
7B12
,
8CVS
,
4R67
,
5LEY
,
5VFO
,
5T0I
,
5LEZ
,
8CXB
,
5T0H
,
7QYA
,
8CVR
,
7W3J
,
6XMJ
,
7NAN
,
6REY
,
5VFQ
,
7W3I
,
5VFP
,
7LXV
,
7W3M
,
6MSB
,
5M32
,
5LF6
,
7W3K
,
5T0C
,
7W3F
,
6E5B
,
6R70
,
5LF7
,
5LN3
,
6MSE
,
5GJR
,
6MSD
,
6KWY
,
5A0Q
,
5VFU
,
6AVO
,
4R3O
,
5VFT
,
5T0G
,
7W3C
,
7QXN
,
7W3H
,
7W38
,
7NHT
,
5L4G
,
7V5G
,
5LF1
,
6MSG
,
7W37
,
5LF0
,
7W3G
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.718
6
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.669
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.638
3
UniProt:Q9NW38 FANCL
2
FANCL [nucleoplasm]
(R-HSA-419520)
FANCL [cytosol]
(R-HSA-420789)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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