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PSMB4 [nucleoplasm]
Stable Identifier
R-HSA-174343
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit beta type 4, Proteasome subunit beta type 4 precursor , Proteasome beta chain, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome chain 3, HSN3, HsBPROS26
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMB4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P28070 PSMB4
Gene Names
PSMB4, PROS26
Chain
propeptide:1-45, chain:46-264
Reference Genes
BioGPS Gene:5692 PSMB4
COSMIC (genes):PSMB4 PSMB4
CTD Gene:5692 PSMB4
dbSNP Gene:5692 PSMB4
ENSEMBL:ENSG00000159377 PSMB4
ENSEMBL_homo_sapiens_GENE:ENSG00000159377.11 PSMB4
HGNC:9541 PSMB4
KEGG Gene (Homo sapiens):5692 PSMB4
Monarch:5692 PSMB4
NCBI Gene:5692 PSMB4
OMIM:602177 PSMB4
UCSC:P28070 PSMB4
Reference Transcript
RefSeq:NM_002796.2 PSMB4
Other Identifiers
11715407_s_at
11715408_x_at
11754271_a_at
1311_at
16670850
202243_PM_s_at
202243_s_at
202244_PM_at
202244_at
2358907
2358908
2358909
2358911
2358912
2358913
2358914
2358916
2358919
2358921
2358923
33154_at
5692
7905395
A_23_P761
D26600_at
GE81194
GO:0000502
GO:0001530
GO:0002376
GO:0002862
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005815
GO:0005829
GO:0005839
GO:0005856
GO:0005929
GO:0006954
GO:0008289
GO:0010498
GO:0019774
GO:0030163
GO:0036064
GO:0043161
GO:0043226
GO:0051603
GO:0070062
HMNXSV003013847
ILMN_1737862
PH_hs_0004994
g4506198_3p_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMB4 [cytosol]
Inferred To
pbs-7 [nucleoplasm]
(Caenorhabditis elegans)
psmB4-1 [nucleoplasm]
(Dictyostelium discoideum)
Prosbeta7 [nucleoplasm]
(Drosophila melanogaster)
Psmb4 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of PSMB4 [nucleoplasm]
(Canis familiaris)
Ghost homologue of PSMB4 [nucleoplasm]
(Danio rerio)
Ghost homologue of PSMB4 [nucleoplasm]
(Sus scrofa)
PSMB4 [nucleoplasm]
(Bos taurus)
PSMB4 [nucleoplasm]
(Gallus gallus)
Proteasome subunit beta type-4 [nucleoplasm]
(Mus musculus)
Cross References
RefSeq
NP_002787.2
OpenTargets
ENSG00000159377
HPA
ENSG00000159377-PSMB4
GeneCards
P28070
Ensembl
ENSG00000159377
,
ENST00000290541
,
ENSP00000290541
PRO
P28070
Pharos - Targets
P28070
Orphanet
24830
PDB
7W38
,
7NAQ
,
7W37
,
7W3I
,
7LXV
,
7AWE
,
7W3H
,
5M32
,
5T0C
,
4R67
,
7NAO
,
5LE5
,
5VFT
,
7W3G
,
6RGQ
,
6REY
,
5VFU
,
6KWY
,
5VFS
,
4R3O
,
7PG9
,
5LEZ
,
6AVO
,
8CXB
,
6E5B
,
5VFR
,
5LEY
,
7W3C
,
6MSB
,
7W3B
,
5T0J
,
7NHT
,
7QXP
,
5GJR
,
5LEX
,
5VFQ
,
6R70
,
5VFP
,
7B12
,
5GJQ
,
7V5M
,
7W39
,
7QYA
,
5LN3
,
5LF6
,
7W3K
,
5T0G
,
6MSJ
,
7V5G
,
5LF4
,
7NAP
,
6XMJ
,
7W3M
,
6MSH
,
7QY7
,
5L4G
,
6MSG
,
7QXX
,
7NAN
,
5LF3
,
7QXW
,
7W3F
,
5LF1
,
6MSE
,
6MSD
,
7QXU
,
8CVR
,
5LF0
,
5A0Q
,
8CVS
,
8CVT
,
7W3A
,
6WJN
,
7QXN
,
5T0I
,
5LF7
,
6MSK
,
5VFO
,
7QYB
,
5T0H
,
6WJD
,
7W3J
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.556
3
UniProt:Q16512 PKN1
3
p-T774-PKN1 [nucleoplasm]
(R-HSA-5625721)
p-T774-PKN1 [cytosol]
(R-HSA-5623651)
PKN1 [cytosol]
(R-HSA-5623613)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.495
2
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