Reactome | PSMB5 [nucleoplasm]

PSMB5 [nucleoplasm]

Stable Identifier

R-HSA-174344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Proteasome subunit beta type 5, Proteasome subunit beta type 5 precursor , Proteasome epsilon chain, Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome subunit X, Proteasome chain 6, Proteasome subunit MB1

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Cyclin E associated events during G1/S transition (Homo sapiens)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
        
        Degradation of multiubiquitinated Cdh1 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
      - SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)

Developmental Biology (Homo sapiens)

- Gastrulation (Homo sapiens)
  - Formation of paraxial mesoderm (Homo sapiens)
    - Somitogenesis (Homo sapiens)
      - RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
        
        TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX2 (Homo sapiens)
      - Regulation of RUNX2 expression and activity (Homo sapiens)
        
        26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX3 (Homo sapiens)
      - Regulation of RUNX3 expression and activity (Homo sapiens)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Hedgehog (Homo sapiens)
  - Hedgehog 'on' state (Homo sapiens)
    - GLI2,3 are degraded by the proteasome (Homo sapiens)
      - 26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)
- Signaling by NOTCH (Homo sapiens)
  - Signaling by NOTCH4 (Homo sapiens)
    - Negative regulation of NOTCH4 signaling (Homo sapiens)
      - Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        20S core particle [nucleoplasm] (Homo sapiens)
        
        20S CP inner ring [nucleoplasm] (Homo sapiens)
        
        PSMB5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P28074 PSMB5

Gene Names

PSMB5, LMPX, MB1, X

Chain

propeptide:1-59, chain:60-263

Reference Genes

BioGPS Gene:5693 PSMB5

COSMIC (genes):PSMB5 PSMB5

CTD Gene:5693 PSMB5

dbSNP Gene:5693 PSMB5

ENSEMBL:ENSG00000100804 PSMB5

HGNC:9542 PSMB5

KEGG:hsa:5693 PSMB5

Monarch:5693 PSMB5

NCBI Gene:5693 PSMB5

OMIM:600306 PSMB5

UCSC:P28074 PSMB5

Reference Transcript

Other Identifiers

11717105_a_at

11717106_x_at

11719787_x_at

11732666_s_at

11754009_a_at

16790659

208799_PM_at

208799_at

3557049

3557052

3557053

3557054

3557055

3557056

3557057

3557058

3557059

3557061

37666_at

5693

7977879

A_23_P37191

GE79699

GO:0000502

GO:0003824

GO:0004175

GO:0004298

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005839

GO:0006508

GO:0006979

GO:0008233

GO:0016787

GO:0019774

GO:0030163

GO:0043161

GO:0043226

GO:0051603

GO:0070062

GO:0140096

HMNXSV003021336

HMNXSV003046393

ILMN_1744649

PH_hs_0019777

TC14000946.hg

X95586_at

g13278740_3p_at

Participates

as a component of

20S CP inner ring [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMB5 [cytosol]

pro-PSMB5 [cytosol]

PSMB5(1-59) [cytosol]

Inferred To

PSMB5 [nucleoplasm] (Bos taurus)

PSMB5 [nucleoplasm] (Canis familiaris)

PSMB5 [nucleoplasm] (Mus musculus)

PSMB5 [nucleoplasm] (Rattus norvegicus)

PSMB5 [nucleoplasm] (Sus scrofa)

psmb5 [nucleoplasm] (Danio rerio)

Ghost homologue of PSMB5 [nucleoplasm] (Gallus gallus)

Ghost homologue of PSMB5 [nucleoplasm] (Xenopus tropicalis)

pbs-5 [nucleoplasm] (Caenorhabditis elegans)

psmB5 [nucleoplasm] (Dictyostelium discoideum)

Prosbeta5 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001124197.1, NP_002788.1, NP_001138404.1

ZINC - World Drugs

PSB5_HUMAN

Guide to Pharmacology - Targets

2406

OpenTargets

ENSG00000100804

ENSEMBL

ENST00000493471, ENSP00000395206, ENSP00000355325, ENSP00000452424, ENST00000361611, ENST00000425762

ZINC - FDA approved

PSB5_HUMAN

ZINC - Substances

PSB5_HUMAN

ZINC - Biogenic

PSB5_HUMAN

ZINC target

P28074

PRO

P28074

GlyGen

P28074

PDB

6MSD, 8QYS, 7NHT, 7QXW, 7QY7, 7QXX, 7QXP, 8QZ9, 7W3C, 8CVR, 5T0C, 5T0I, 5LN3, 5T0H, 5LEY, 5L5W, 5L61, 7LXV, 5L5X, 5LEZ, 4R67, 5LF3, 8CXB, 8CVS, 8CVT, 6REY, 6R70, 8BZL, 7QYB, 7V5M, 5VFU, 6MSH, 7W37, 5VFR, 7NAP, 7W3A, 5VFO, 7W3I, 5LF1, 7NAO, 8QYO, 6KWY, 5VFT, 7NAQ, 6MSJ, 7W3H, 5GJQ, 6MSE, 7V5G, 5GJR, 7W3F, 7QXN, 7W3M, 7W3K, 5M32, 5LE5, 4R3O, 5T0J, 5T0G, 5LEX, 5L62, 5LF6, 5L5Y, 5LF7, 5L60, 5LF4, 5L4G, 7PG9, 7QYA, 5L64, 5L5Z, 5L63, 8QYN, 7W39, 7NAN, 7QXU, 7W3G, 5A0Q, 6XMJ, 5VFQ, 7W3J, 8UD9, 6MSG, 5VFP, 6WJN, 6RGQ, 5LF0, 6WJD, 5VFS, 7W38, 6MSK, 7W3B, 6MSB

ZINC - Investigational

PSB5_HUMAN

HPA

ENSG00000100804-PSMB5

Pharos - Targets

P28074

ZINC - Predictions - Purchasable

PSB5_HUMAN

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99436 PSMB7	7	PSMB7 [cytosol] (R-HSA-68759) PSMB7 [nucleoplasm] (R-HSA-174331) PSMB7 [secretory granule lumen] (R-HSA-6803279) PSMB7 [extracellular region] (R-HSA-6806449) PSMB7 [ficolin-1-rich granule lumen] (R-HSA-6803312) pro-PSMB7 [cytosol] (R-HSA-9908145) PSMB7(1-43) [cytosol] (R-HSA-9908129)	0.804	10
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143)	0.804	7
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.794	9
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.745	6
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.738	5
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.725	6
UniProt:Q9Y244 POMP	1	POMP [cytosol] (R-HSA-9908067)	0.667	4
UniProt:O15116 LSM1	1	LSM1 [cytosol] (R-HSA-429976)	0.666	4
UniProt:P28070 PSMB4	4	PSMB4 [cytosol] (R-HSA-68750) PSMB4 [nucleoplasm] (R-HSA-174343) pro-PSMB4 [cytosol] (R-HSA-9908138) PSMB4(1-45) [cytosol] (R-HSA-9908122)	0.659	4
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.643	4
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.643	5
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.564	2
UniProt:O95429 BAG4	3	BAG4 [cytosol] (R-HSA-5212670) BAG4(1-126)-p-8Y-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853156) BAG4(1-126)-FGFR1(208-822) fusion [plasma membrane] (R-HSA-8853157)	0.556	5
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q68J44 DUS29			0.556	3
IntAct:EBI-18719940 GG12G			0.556	3
UniProt:Q9BT92 TCHP			0.556	3
UniProt:Q92989 CLP1	1	CLP1 [nucleoplasm] (R-HSA-72017)	0.556	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.556	3
UniProt:Q8NCX0-3 CCDC150			0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q14997 PSME4	1	PSME4 [cytosol] (R-HSA-947606)	0.527	2
UniProt:P28066 PSMA5	5	PSMA5 [cytosol] (R-HSA-68732) PSMA5 [nucleoplasm] (R-HSA-174340) PSMA5 [secretory granule lumen] (R-HSA-6803316) PSMA5 [extracellular region] (R-HSA-6806459) PSMA5 [ficolin-1-rich granule lumen] (R-HSA-6803328)	0.527	4
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.495	2

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