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PSMA2 [nucleoplasm]
Stable Identifier
R-HSA-174345
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome subunit alpha type 2 , Proteasome component C3, Macropain subunit C3, Multicatalytic endopeptidase complex subunit C3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25787 PSMA2
Gene Names
PSMA2, HC3, PSC3
Chain
initiator methionine:1, chain:2-234
Reference Genes
BioGPS Gene:5683 PSMA2
COSMIC (genes):PSMA2 PSMA2
CTD Gene:5683 PSMA2
dbSNP Gene:5683 PSMA2
ENSEMBL:ENSG00000106588 PSMA2
HGNC:9531 PSMA2
KEGG Gene (Homo sapiens):5683 PSMA2
Monarch:5683 PSMA2
NCBI Gene:5683 PSMA2
OMIM:176842 PSMA2
UCSC:P25787 PSMA2
Reference Transcript
RefSeq:NM_002787.4 PSMA2
Other Identifiers
0002970162
11719275_a_at
11757361_x_at
1446_at
17057035
201316_at
201317_s_at
2523133
3047965
3047966
3047967
3047968
3047969
3047970
3047971
3047972
3047977
3047979
3047980
3047983
3047984
3047988
41240_at
4R3O
4R67
5683
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
8139232
8188
A_23_P345591
AAH02900
AAH47697
AK290654
BAA00657
BAF83343
BC002900
BC047697
C9JCK5
CAG29313
CCDS5467
CH236951
CH471073
CR450317
D00760
D00760_at
EAL24005
EAW94152
ENSG00000106588
ENSP00000223321
ENST00000223321
ENST00000223321.8
EntrezGene:5683
EntrezGene:PSMA2
F8WEG3
g4506180_3p_a_at
GE79408
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0000932
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0004175
GO:0004298
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005839
GO:0006464
GO:0006508
GO:0006511
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008233
GO:0009056
GO:0009058
GO:0009615
GO:0010498
GO:0010499
GO:0010972
GO:0016192
GO:0016579
GO:0016787
GO:0019773
GO:0030154
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0038061
GO:0038095
GO:0043161
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0051603
GO:0055085
GO:0060071
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
H7C402
HGNC:9531
HPA008188
Hs.181309.0.S2_3p_at
ILMN_1682553
ILMN_2058512
IPR000426
IPR001353
IPR023332
IPR029055
IPR034644
MIM:176842
NM_002787
NP_002778
PF00227
PF10584
PH_hs_0023846
PH_hs_0035799
PSMA2
PSMA2-201
SM00948
TC07003353.hg
UPI000004D00F
Participant Of
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSMA2 [secretory granule lumen]
PSMA2 [extracellular region]
PSMA2 [ficolin-1-rich granule lumen]
PSMA2 [cytosol]
Inferred To
PSMA2 [nucleoplasm] (Bos taurus)
PSMA2 [nucleoplasm] (Caenorhabditis elegans)
PSMA2 [nucleoplasm] (Canis familiaris)
PSMA2 [nucleoplasm] (Danio rerio)
PSMA2 [nucleoplasm] (Dictyostelium discoideum)
PSMA2 [nucleoplasm] (Drosophila melanogaster)
PSMA2 [nucleoplasm] (Rattus norvegicus)
PSMA2 [nucleoplasm] (Sus scrofa)
PSMA2 [nucleoplasm] (Xenopus tropicalis)
Homologues of PSMA2 [nucleoplasm] (Danio rerio)
Proteasome subunit alpha type-2 [nucleoplasm] (Mus musculus)
Cross References
RefSeq
NP_002778.1
OpenTargets
ENSG00000106588
GeneCards
P25787
PRO
P25787
PDB
5LF1
,
5VFO
,
5T0J
,
6MSJ
,
5LEZ
,
5LF0
,
5T0I
,
5LE5
,
5LF3
,
5VFP
,
6MSH
,
5VFU
,
4R67
,
5T0H
,
5A0Q
,
5T0G
,
5LEY
,
5L4G
,
6MSG
,
5VFS
,
5LF7
,
5M32
,
5VFT
,
6AVO
,
5T0C
,
6MSE
,
6MSD
,
5GJR
,
4R3O
,
5LEX
,
5LF4
,
6MSK
,
5VFQ
,
6MSB
,
5GJQ
,
5LN3
,
5LF6
,
5VFR
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.527
3
UniProt:Q6VN20 RANBP10
1
RANBP10 [cytosol]
(R-HSA-8851865)
0.508
2
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