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PSMD1 [nucleoplasm]
Stable Identifier
R-HSA-174348
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S proteasome non-ATPase regulatory subunit 1, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Somitogenesis (Homo sapiens)
RIPPLY2 binds TBX6 and recruits the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
TBX6:RIPPLY2:26S proteasome [nucleoplasm] (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMD1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99460 PSMD1
Gene Names
PSMD1
Chain
chain:1-953
Reference Genes
BioGPS Gene:5707 PSMD1
COSMIC (genes):PSMD1 PSMD1
CTD Gene:5707 PSMD1
dbSNP Gene:5707 PSMD1
ENSEMBL:ENSG00000173692 PSMD1
ENSEMBL_homo_sapiens_GENE:ENSG00000173692.14 PSMD1
HGNC:9554 PSMD1
KEGG Gene (Homo sapiens):5707 PSMD1
Monarch:5707 PSMD1
NCBI Gene:5707 PSMD1
OMIM:617842 PSMD1
UCSC:Q99460 PSMD1
Reference Transcript
RefSeq:NM_001191037.1 PSMD1
RefSeq:NM_002807.3 PSMD1
Other Identifiers
11743902_at
11756579_a_at
1314_at
16892039
201198_PM_s_at
201198_s_at
201199_PM_s_at
201199_s_at
2531713
2531714
2531715
2531717
2531718
2531719
2531720
2531721
2531722
2531723
2531724
2531726
2531728
2531729
2531730
2531731
2531732
2531733
2531737
2531748
2531750
2531753
2531755
2531758
2531761
2531762
2531763
2531767
2531768
2531769
2531770
2531771
51788_at
5707
8049016
A_23_P209740
A_24_P128205
D44466_at
GE57222
GO:0000502
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005764
GO:0005773
GO:0005829
GO:0005838
GO:0008540
GO:0016020
GO:0022624
GO:0030163
GO:0030234
GO:0031410
GO:0031625
GO:0034515
GO:0035578
GO:0042176
GO:0043161
GO:0043226
GO:0098772
HMNXSV003045385
Hs.3887.0.S1_3p_a_at
ILMN_1702837
PH_hs_0000438
TC02001386.hg
TC02003882.hg
g4506224_3p_a_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMD1 [extracellular region]
PSMD1 [azurophil granule lumen]
PSMD1 [cytosol]
Inferred To
Psmd1 [nucleoplasm]
(Mus musculus)
Psmd1 [nucleoplasm]
(Rattus norvegicus)
psmD1 [nucleoplasm]
(Dictyostelium discoideum)
zgc:55818 [nucleoplasm]
(Danio rerio)
PSMD1 [nucleoplasm]
(Bos taurus)
PSMD1 [nucleoplasm]
(Canis familiaris)
PSMD1 [nucleoplasm]
(Gallus gallus)
PSMD1 [nucleoplasm]
(Sus scrofa)
Rpn2 [nucleoplasm]
(Drosophila melanogaster)
rpn-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002798.2
,
NP_001177966.1
OpenTargets
ENSG00000173692
GeneCards
Q99460
HPA
ENSG00000173692-PSMD1
Ensembl
ENSP00000362738
,
ENST00000677230
,
ENST00000308696
,
ENST00000373635
,
ENSG00000173692
,
ENSP00000309474
,
ENSP00000503068
PRO
Q99460
Pharos - Targets
Q99460
PDB
5M32
,
6MSH
,
5VGZ
,
7W3C
,
5VFS
,
5T0C
,
6MSG
,
5VFR
,
7QXW
,
6OI4
,
5T0G
,
5VHF
,
6WJD
,
7QXU
,
7W3J
,
6UYI
,
5L4K
,
6WJN
,
5V1Y
,
5T0I
,
7W37
,
5VFU
,
5T0H
,
7W3A
,
7W3M
,
5VFP
,
7QYA
,
6UYJ
,
5LN3
,
5V1Z
,
7W38
,
7W3K
,
5GJR
,
6CO4
,
7W3F
,
7QXP
,
5GJQ
,
5VFQ
,
7QXN
,
7QYB
,
7W3B
,
7W3H
,
6MSK
,
6MSJ
,
7W3G
,
8CVT
,
5VFT
,
5VHI
,
6MSD
,
7QY7
,
7W3I
,
7QXX
,
5VHH
,
6MSB
,
5VHS
,
6MSE
,
5T0J
,
7W39
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.676
5
UniProt:O00487 PSMD14
5
PSMD14 [secretory granule lumen]
(R-HSA-6800926)
PSMD14 [extracellular region]
(R-HSA-6806511)
PSMD14 [ficolin-1-rich granule lumen]
(R-HSA-6800419)
PSMD14 [nucleoplasm]
(R-HSA-174329)
PSMD14 [cytosol]
(R-HSA-68722)
0.564
2
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.564
3
UniProt:P62333 PSMC6
2
PSMC6 [nucleoplasm]
(R-HSA-174319)
PSMC6 [cytosol]
(R-HSA-68783)
0.553
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
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