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PSME2 [nucleoplasm]
Stable Identifier
R-HSA-174350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Proteasome activator complex subunit 2, Proteasome activator 28-beta subunit, PA28beta, PA28b, Activator of multicatalytic protease subunit 2, 11S regulator complex beta subunit, REG-beta
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Proteasome activator complex subunit 2 (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSME2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UL46 PSME2
Gene Names
PSME2
Chain
initiator methionine:1, chain:2-239
Reference Genes
BioGPS Gene:5721 PSME2
COSMIC (genes):PSME2 PSME2
CTD Gene:5721 PSME2
dbSNP Gene:5721 PSME2
ENSEMBL:ENSG00000100911 PSME2
ENSEMBL:ENSG00000284889 PSME2
HGNC:9569 PSME2
KEGG Gene (Homo sapiens):5721 PSME2
Monarch:5721 PSME2
NCBI Gene:5721 PSME2
OMIM:602161 PSME2
UCSC:Q9UL46 PSME2
Reference Transcript
RefSeq:NM_002818.2 PSME2
Other Identifiers
0005700333
1184_at
16791059
201762_s_at
2749686
2749687
2821648
3238435
3489180
3489181
3489182
3557812
3557813
3557815
3557817
3557819
3557820
3557823
3557825
3557827
3557829
3557832
3557834
41171_at
5721
7978123
A_23_P65427
D45248_at
GE81197
GO:0000165
GO:0000209
GO:0000278
GO:0000502
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008537
GO:0009056
GO:0009058
GO:0010950
GO:0010972
GO:0016020
GO:0016579
GO:0030154
GO:0030234
GO:0031145
GO:0031146
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0035722
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061133
GO:0061136
GO:0061418
GO:0070062
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:2000045
TC14000968.hg
g4506236_3p_a_at
Participant Of
output
Expression of Proteasome activator complex subunit 2
hasComponent
26S proteasome [nucleoplasm]
Other forms of this molecule
PSME2 [cytosol]
Inferred To
psmE3 [nucleoplasm] (Dictyostelium discoideum)
PSME2 [nucleoplasm] (Caenorhabditis elegans)
PSME2 [nucleoplasm] (Canis familiaris)
PSME2 [nucleoplasm] (Sus scrofa)
PSME2 [nucleoplasm] (Xenopus tropicalis)
psme2 [nucleoplasm] (Danio rerio)
Psme2 [nucleoplasm] (Mus musculus)
Psme2 [nucleoplasm] (Rattus norvegicus)
REG [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
NP_002809.2
Target Pathogen
5b354852be737e166372ea0f
OpenTargets
ENSG00000100911
HPA
ENSG00000100911-PSME2
GeneCards
Q9UL46
Ensembl
ENSP00000216802
,
ENSP00000495790
,
ENSG00000284889
,
ENSG00000100911
,
ENST00000216802
,
ENST00000645325
PRO
Q9UL46
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UL46 PSME2
2
PSME2 [cytosol]
(R-HSA-68814)
PSME2 [nucleoplasm]
(R-HSA-174350)
0.718
6
UniProt:Q06323 PSME1
2
PSME1 [cytosol]
(R-HSA-68812)
PSME1 [nucleoplasm]
(R-HSA-174320)
0.666
6
UniProt:O00560 SDCBP
3
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q9BZL1 UBL5
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9BVJ7 DUS23
0.556
3
UniProt:P28065 PSMB9
2
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9 [nucleoplasm]
(R-HSA-174334)
0.527
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.527
9
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