GCL ligates L-Glu to L-Cys

Stable Identifier
R-HSA-174367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Glutamate and cysteine combine
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The first step in the formation of glutathione is the ligation of glutamate with cysteine, catalysed by the dimeric protein glutamate-cysteine ligase, GCL (Gipp et al. 1995, Misra & Griffith 1998).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutamate-cysteine ligase activity of GCL [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created