MTR transfers CH3 from MeCbl to HCYS

Stable Identifier
R-HSA-174374
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Methionine is reformed
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A methyl group from 5-methyltetrahydrofolate is transferred to homocysteine (HCYS) via a meCbl intermediate, forming methionine (L-Met) (Leclerc et al. 1996).

Literature References
PubMed ID Title Journal Year
8968737 Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders

Leclerc, D, Campeau, E, Goyette, P, Adjalla, CE, Christensen, B, Ross, M, Eydoux, P, Rosenblatt, DS, Rozen, R, Gravel, RA

Hum Mol Genet 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methionine synthase activity of MTRR:MTR(MeCbl) [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created