Reactome | MTR [cytosol]

MTR [cytosol]

Stable Identifier

R-HSA-174376

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Methionine synthase

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of metabolism (Homo sapiens)
  - Defects in vitamin and cofactor metabolism (Homo sapiens)
    - Defects in cobalamin (B12) metabolism (Homo sapiens)
      - Defective MTRR causes HMAE (Homo sapiens)
        
        Defective MTRR does not convert cob(II)alamin to MeCbl (Homo sapiens)
        
        mutant MTRR:MTR(cob(II)alamin) [cytosol] (Homo sapiens)
        
        MTR:Zn2+:cob(II)alamin [cytosol] (Homo sapiens)
        
        MTR [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOH GTPase cycle (Homo sapiens)
        
        RHOH binds effectors at the plasma membrane (Homo sapiens)
        
        RHOH effectors [cytosol] (Homo sapiens)
        
        MTR [cytosol] (Homo sapiens)
        
        RHOH:GTP:RHOH effectors [plasma membrane] (Homo sapiens)
        
        RHOH effectors [cytosol] (Homo sapiens)
        
        MTR [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99707 MTR

Gene Names

MTR

Chain

chain:1-1265

Reference Genes

BioGPS Gene:4548 MTR

COSMIC (genes):MTR MTR

CTD Gene:4548 MTR

dbSNP Gene:4548 MTR

ENSEMBL:ENSG00000116984 MTR

HGNC:7468 MTR

KEGG Gene (Homo sapiens):4548 MTR

Monarch:4548 MTR

NCBI Gene:4548 MTR

OMIM:156570 MTR

UCSC:Q99707 MTR

Reference Transcript

Other Identifiers

0001090731

11739412_a_at

11739413_at

11751961_s_at

11751974_a_at

11756051_a_at

16679094

203774_at

226969_at

2387007

2387008

2387009

2387014

2387015

2387016

2387018

2387019

2387020

2387021

2387029

2387030

2387031

2387032

2387035

2387037

2387038

2387039

2387040

2387044

2387045

2387046

2387048

2387049

2387050

2387051

2387054

2387055

2387057

2387060

2387061

2387064

2387067

2387069

2387072

2387073

2387074

2387075

2387076

2387081

2387082

2387083

2387085

38383_at

44615_at

4548

75377_at

7910752

A_14_P132244

A_23_P200930

A_23_P200936

A_24_P67806

A_33_P3389917

GE80903

GO:0000096

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006520

GO:0006790

GO:0006950

GO:0007399

GO:0008150

GO:0008168

GO:0008270

GO:0008652

GO:0008705

GO:0009058

GO:0009086

GO:0009235

GO:0016740

GO:0030154

GO:0031103

GO:0031419

GO:0032259

GO:0042558

GO:0043167

GO:0044237

GO:0044281

GO:0046872

GO:0048678

GO:0048856

GO:0071732

HMNXSV003018013

HMNXSV003030237

Hs.33264.0.A1_3p_at

ILMN_1670801

ILMN_1815141

PH_hs_0040560

TC01001956.hg

TC01005133.hg

U73338_at

g4557764_3p_at

Participates

as a candidate of

RHOH effectors [cytosol] (Homo sapiens)

as a component of

Other forms of this molecule

MTR R585* [cytosol]

MTR P1173L [cytosol]

MTR H920D [cytosol]

MTR Ile881 [cytosol]

MTR A410P [cytosol]

MTR E1204* [cytosol]

Inferred To

metr-1 [cytosol] (Caenorhabditis elegans)

MTR [cytosol] (Canis familiaris)

MTR [cytosol] (Gallus gallus)

MTR [cytosol] (Sus scrofa)

MTR [cytosol] (Xenopus tropicalis)

mtr [cytosol] (Danio rerio)

mtr [cytosol] (Dictyostelium discoideum)

Mtr [cytosol] (Mus musculus)

Mtr [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001278869.1, NP_001278868.1, NP_000245.2

Guide to Pharmacology - Targets

3099

OpenTargets

ENSG00000116984

ZINC - Substances

METH_HUMAN

ZINC target

Q99707

PRO

Q99707

GlyGen

Q99707

PDB

4CCZ, 2O2K

GeneCards

Q99707

HPA

ENSG00000116984-MTR

Ensembl

ENST00000535889, ENSG00000116984, ENSP00000355536, ENST00000366577, ENSP00000441845

Pharos - Targets

Q99707

Orphanet

16485

ZINC - Predictions - Purchasable

METH_HUMAN

HMDB Protein

HMDBP00160

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4U1 MMACHC	6	MMACHC R132* [cytosol] (R-HSA-3318572) MMACHC R91Kfs14 [cytosol] (R-HSA-3318604) MMACHC W203 [cytosol] (R-HSA-3928672) MMACHC R161Q [cytosol] (R-HSA-3318613) MMACHC R111* [cytosol] (R-HSA-3318593) MMACHC [cytosol] (R-HSA-2980949)	0.471	3

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