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GCLC [cytosol]
Stable Identifier
R-HSA-174385
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glutamate--cysteine ligase heavy chain, gamma-glutamylcysteine heavy chain
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)
GCLC [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase II - Conjugation of compounds (Homo sapiens)
Glutathione conjugation (Homo sapiens)
Glutathione synthesis and recycling (Homo sapiens)
GCL ligates L-Glu to L-Cys (Homo sapiens)
GCL [cytosol] (Homo sapiens)
GCLC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48506 GCLC
Gene Names
GCLC, GLCL, GLCLC
Chain
chain:1-637
Reference Genes
BioGPS Gene:2729 GCLC
COSMIC (genes):GCLC GCLC
CTD Gene:2729 GCLC
dbSNP Gene:2729 GCLC
ENSEMBL:ENSG00000001084 GCLC
ENSEMBL_homo_sapiens_GENE:ENSG00000001084.13 GCLC
HGNC:4311 GCLC
KEGG Gene (Homo sapiens):2729 GCLC
Monarch:2729 GCLC
NCBI Gene:2729 GCLC
OMIM:606857 GCLC
UCSC:P48506 GCLC
Reference Transcript
RefSeq:NM_001498.3 GCLC
RefSeq:NM_001197115.1 GCLC
Other Identifiers
11729218_a_at
11750770_a_at
11754931_a_at
202922_PM_at
202922_at
202923_PM_s_at
202923_s_at
2729
2957706
2957707
2957708
2957709
2957710
2957712
2957714
2957715
2957717
2957722
2957724
2957725
2957727
2957730
2957732
2957737
2957738
2957741
2957742
2957750
2957751
2957752
2957767
2957768
2957769
31850_at
49163_at
52591_s_at
52592_r_at
56626_r_at
8127158
A_23_P145114
GE58133
GO:0000166
GO:0000287
GO:0003013
GO:0003824
GO:0004357
GO:0005515
GO:0005524
GO:0005739
GO:0005829
GO:0005975
GO:0006351
GO:0006355
GO:0006520
GO:0006534
GO:0006536
GO:0006575
GO:0006749
GO:0006750
GO:0006766
GO:0006790
GO:0006979
GO:0007005
GO:0007584
GO:0009408
GO:0009410
GO:0009725
GO:0012501
GO:0014823
GO:0016595
GO:0016874
GO:0017109
GO:0019852
GO:0023052
GO:0030163
GO:0031397
GO:0032436
GO:0032869
GO:0035729
GO:0036211
GO:0043066
GO:0043226
GO:0043524
GO:0043531
GO:0044344
GO:0044752
GO:0044877
GO:0045454
GO:0045892
GO:0046685
GO:0046686
GO:0051409
GO:0051900
GO:0061024
GO:0070555
GO:0071260
GO:0071333
GO:0071372
GO:0097069
GO:0097746
GO:1901029
GO:2000490
GO:2001237
HMNXSV003053412
Hs.151393.0.S2_3p_at
ILMN_1730575
ILMN_2215194
M90656_at
TC06004051.hg
g4557624_3p_a_at
Participates
as a component of
GCL [cytosol] (Homo sapiens)
as an output of
AcK-NFE2L2-dependent GCLC gene expression (Homo sapiens)
Other forms of this molecule
GCLC H370L [cytosol]
GCLC P185L [cytosol]
GCLC R127C [cytosol]
Inferred To
Gclc [cytosol]
(Drosophila melanogaster)
Gclc [cytosol]
(Mus musculus)
Gclc [cytosol]
(Rattus norvegicus)
gcs-1 [cytosol]
(Caenorhabditis elegans)
gcs1 [cytosol]
(Schizosaccharomyces pombe)
gclc [cytosol]
(Xenopus tropicalis)
GCLC [cytosol]
(Bos taurus)
GCLC [cytosol]
(Canis familiaris)
GCLC [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001489.1
,
NP_001184044.1
OpenTargets
ENSG00000001084
ZINC - Substances
GSH1_HUMAN
HPA
ENSG00000001084-GCLC
GeneCards
P48506
Ensembl
ENST00000650454
,
ENSG00000001084
,
ENSP00000497574
ZINC target
P48506
PRO
P48506
Pharos - Targets
P48506
Orphanet
16111
ZINC - Predictions - Purchasable
GSH1_HUMAN
HMDB Protein
HMDBP00512
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48507 GCLM
1
GCLM [cytosol]
(R-HSA-174356)
0.59
2
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