MAT1A multimers transfer Ado from ATP to L-Met

Stable Identifier
R-HSA-174391
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
SAM is sythesized from methionine's reaction with ATP
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S-adenosylmethionine (AdoMet, SAM) is an essential metabolite in all cells. AdoMet is a precursor in the synthesis of polyamines. Methionine adenosyltransferases (MAT) catalyse the only known AdoMet biosynthetic reaction from methionine (L-Met) and ATP. In mammalian tissues, three different forms of MAT (MAT I, MAT III and MAT II) have been identified that are the product of two different genes (MAT1A and MAT2A). MAT1A binds 1 K+ and 2 Mg2+ (or Co2+, not shown here) in tetrameric or dimeric form (Corrales et al. 2002, Mato et al. 1997).

Literature References
PubMed ID Title Journal Year
9175157 S-adenosylmethionine synthesis: molecular mechanisms and clinical implications

Mato, JM, Alvarez, L, Ortiz, P, Pajares, MA

Pharmacol Ther 1997
12163696 Regulation of mammalian liver methionine adenosyltransferase

Corrales, FJ, Pérez-Mato, I, Sánchez Del Pino, MM, Ruiz, F, Castro, C, García-Trevijano, ER, Latasa, U, Martinez-Chantar, ML, Martinez-Cruz, A, Avila, MA, Mato, JM

J Nutr 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methionine adenosyltransferase activity of MAT1A multimers [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created