RPA binds to the Flap on the C-strand

Stable Identifier
R-HSA-174445
Type
Reaction [binding]
Species
Homo sapiens
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The first step in the removal of the flap intermediate is the binding of Replication Protein A (RPA) to the long flap structure. RPA is a eukaryotic single-stranded DNA binding protein (Bae et al. 2001). Binding of RPA to the single strand DNA during telomeric strand displacement synthesis is necessary for the recruitment of DNA2. DNA2 is a helicase/endonuclease that resolves G quadruplexes (G4), which are DNA structures that commonly form in polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008). DNA2 also removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001).

Literature References
PubMed ID Title Journal Year
18593712 Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition

Masuda-Sasa, T, Polaczek, P, Peng, XP, Chen, L, Campbell, JL

J. Biol. Chem. 2008
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