Recruitment of DNA2 endonuclease to the C strand

Stable Identifier
R-HSA-174451
Type
Reaction
Species
Homo sapiens
Compartment
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After RPA binds the long flap, it recruits the DNA2 helicase/endonuclease which removes the initiator RNA primers of Okazaki fragments (Bae et al. 2001). DNA2 is also needed to resolve G quadruplexes (G4), DNA structures commonly formed by polyguanine-rich telomeric DNA sequences (Masuda-Sasa et al. 2008, Lin et al. 2013).

Literature References
PubMed ID Title Journal Year
18593712 Processing of G4 DNA by Dna2 helicase/nuclease and replication protein A (RPA) provides insights into the mechanism of Dna2/RPA substrate recognition

Masuda-Sasa, T, Polaczek, P, Peng, XP, Chen, L, Campbell, JL

J. Biol. Chem. 2008
23604072 Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

Lin, W, Sampathi, S, Dai, H, Liu, C, Zhou, M, Hu, J, Huang, Q, Campbell, J, Shin-Ya, K, Zheng, L, Chai, W, Shen, B

EMBO J. 2013
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