Membrane binding and targetting of GAG proteins

Stable Identifier
R-HSA-174490
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Locations in the PathwayBrowser
General
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One of the mysteries of Gag protein involvement in HIV virion assembly is how the proteins are targeted to the proper membrane for budding. Infectious retroviruses do not bud from all of the available membrane surfaces within an infected cell, but primarily from the plasma membrane, which constitutes a small proportion of the total membrane surface in most cells. In polarized cells, the sites of budding are further restricted to the basolateral membrane.

Literature References
PubMed ID Title Journal Year
15473846 Retrovirus budding

Morita, E, Sundquist, WI

Annu Rev Cell Dev Biol 2004
16683918 Identification of an intracellular trafficking and assembly pathway for HIV-1 gag

Perlman, M, Resh, MD

Traffic 2006
Participants
Participant Of
Event Information
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease 526 HIV infection
Cross References
BioModels Database
Authored
Reviewed
Created