Reactome | P4HB [endoplasmic reticulum lumen]

P4HB [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-174692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

P4HB reduced, PDIA1, Protein disulfide isomerase A1

Locations in the PathwayBrowser for interactor UniProt:O15534 PER1

Expand all

External Reference Information

External Reference

UniProt:P07237 P4HB

Gene Names

P4HB, ERBA2L, PDI, PDIA1, PO4DB

Chain

signal peptide:1-17, chain:18-508

Reference Genes

BioGPS Gene:5034 P4HB

COSMIC (genes):P4HB P4HB

CTD Gene:5034 P4HB

dbSNP Gene:5034 P4HB

ENSEMBL:ENSG00000185624 P4HB

ENSEMBL_homo_sapiens_GENE:ENSG00000185624.16 P4HB

HGNC:8548 P4HB

KEGG Gene (Homo sapiens):5034 P4HB

Monarch:5034 P4HB

NCBI Gene:5034 P4HB

OMIM:176790 P4HB

UCSC:P07237 P4HB

Reference Transcript

RefSeq:NM_000918.3 P4HB

Other Identifiers

11716173_a_at

11716174_s_at

11716175_x_at

11752448_a_at

11752449_x_at

11752645_a_at

1564494_PM_s_at

1564494_s_at

200654_PM_at

200654_at

200656_PM_s_at

200656_s_at

36666_at

3774242

3774243

3774244

3774245

3774246

3774247

3774250

3774251

3774252

3774256

3774258

3774259

3774260

3774261

3774262

3774263

3774268

3774270

3774276

3774281

3774282

4041341

4041343

4041344

4041345

4041346

4041347

4041348

4041349

4041350

4041351

4041355

4041358

4041359

4041360

4041361

4041362

4041367

4041368

4041369

4041373

4041374

4041376

4041377

5034

691_g_at

8019250

8019762

A_23_P107412

A_33_P3252043

GE80965

GO:0003723

GO:0003756

GO:0003779

GO:0003824

GO:0004656

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005793

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0006457

GO:0006888

GO:0007155

GO:0008092

GO:0009897

GO:0012501

GO:0015035

GO:0016020

GO:0016192

GO:0016222

GO:0016491

GO:0016853

GO:0016972

GO:0018401

GO:0019899

GO:0023052

GO:0030027

GO:0030070

GO:0031410

GO:0032991

GO:0034663

GO:0034975

GO:0034976

GO:0035722

GO:0036211

GO:0038155

GO:0042470

GO:0043226

GO:0044877

GO:0045785

GO:0046598

GO:0046982

GO:0051604

GO:0070062

GO:0071456

GO:0098761

GO:0140096

GO:1900026

GO:1902175

HMNXSV003029683

Hs2.397055.1.S1_3p_s_at

ILMN_1719303

J02783_at

PH_hs_0019534

TC17001960.hg

X05130_s_at

g4505566_3p_a_at

Participates

as an input of

as an output of

as a component of

as a member of

FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

p-P4HB [endoplasmic reticulum lumen]

HC53,56-P4HB [endoplasmic reticulum lumen]

Inferred To

p4hb [endoplasmic reticulum lumen] (Danio rerio)

p4hb [endoplasmic reticulum lumen] (Xenopus tropicalis)

Homologues of P4HB [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Homologues of P4HB [endoplasmic reticulum lumen] (Dictyostelium discoideum)

pdi-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

P4HB [endoplasmic reticulum lumen] (Bos taurus)

P4HB [endoplasmic reticulum lumen] (Caenorhabditis elegans)

P4HB [endoplasmic reticulum lumen] (Canis familiaris)

P4HB [endoplasmic reticulum lumen] (Dictyostelium discoideum)

P4HB [endoplasmic reticulum lumen] (Gallus gallus)

P4HB [endoplasmic reticulum lumen] (Plasmodium falciparum)

P4HB [endoplasmic reticulum lumen] (Sus scrofa)

P4hb [endoplasmic reticulum lumen] (Mus musculus)

P4hb [endoplasmic reticulum lumen] (Rattus norvegicus)

pdi-2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Pdi [endoplasmic reticulum lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_000909.2

OpenTargets

ENSG00000185624

IntEnz

5.3.4.1

GeneCards

P07237

HPA

ENSG00000185624-P4HB

Ensembl

ENSP00000327801, ENST00000331483, ENSG00000185624

PRO

P07237

Pharos - Targets

P07237

Orphanet

23211

HMDB Protein

HMDBP02802

PDB

1X5C, 4EL1, 4EKZ, 1BJX, 4JU5, 1MEK, 8EOJ, 8GDY, 3UEM, 2BJX, 6I7S, 7ZSC, 3BJ5, 2K18

Interactors (60)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.713	6
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.666	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.658	17
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.657	4
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.656	3
UniProt:Q9UBS9 SUCO			0.643	3
UniProt:Q8TDX7 NEK7	2	p-S195-NEK7 [cytosol] (R-HSA-2984246) NEK7 [cytosol] (R-HSA-2530599)	0.638	3
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.576	3
ChEBI:28304 HEPARIN			0.57	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.564	2
UniProt:Q5T0J7-2 TEX35			0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:Q8NEG0 GAR6			0.556	3
UniProt:P17655 CAPN2	2	CAPN2 [plasma membrane] (R-HSA-8863405) CAPN2 [cytosol] (R-HSA-8848630)	0.556	3
UniProt:Q14990 ODFP1			0.556	3
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.556	3
UniProt:Q86WV1-2 SKAP1			0.556	3
UniProt:Q5TA82 LCE2D	1	LCE2D [cytosol] (R-HSA-6814300)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:Q92692-2 NECTIN2			0.556	3
UniProt:P09228 CYTT			0.556	3
UniProt:P60328 KRTAP12-3	1	KRTAP12-3 [cytosol] (R-HSA-6810284)	0.556	3
UniProt:CCDC26 A0A024R9H7			0.556	3
UniProt:Q494V2-2 CFAP100			0.556	3
UniProt:O00444 PLK4	1	PLK4 [cytosol] (R-HSA-380286)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3
UniProt:Q9P121-3 NTM			0.556	3
UniProt:Q5T7P3 LCE1B	1	LCE1B [cytosol] (R-HSA-6814271)	0.556	3
UniProt:Q5TA78 LCE4A	1	LCE4A [cytosol] (R-HSA-6814272)	0.556	3
UniProt:O15534 PER1	4	p-S-PER1 [cytosol] (R-HSA-400310) p-S-PER1 [nucleoplasm] (R-HSA-3325590) PER1 [cytosol] (R-HSA-400373) Ub-p-S-PER1 [cytosol] (R-HSA-517831)	0.556	3
UniProt:Q52LG2 KRTAP13-2	1	KRTAP13-2 [cytosol] (R-HSA-6810274)	0.556	3
UniProt:Q9ULW2 FZD10	1	FZD10 [plasma membrane] (R-HSA-443943)	0.556	3
UniProt:Q9UC07-2 ZNF69			0.556	3
UniProt:O94818-2 NOL4			0.556	3
UniProt:Q8NE01 CNNM3			0.556	3
UniProt:Q9NU02 ANKE1			0.556	3
UniProt:Q53R41 FAKD1			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:P02538 KRT6A	1	KRT6A [cytosol] (R-HSA-6809654)	0.556	3
UniProt:Q8N4N3-2 KLHL36			0.556	3
UniProt:P62873 GNB1	5	GNB1 [photoreceptor disc membrane] (R-HSA-55373) Unfolded GNB1 [cytosol] (R-HSA-6814200) Partially folded GNB1 [cytosol] (R-HSA-8850526) GNB1 [plasma membrane] (R-HSA-164347) GNB1 [cytosol] (R-HSA-6814412)	0.556	3
UniProt:Q9P2K6 KLHL42	1	KLHL42 [cytosol] (R-HSA-8863204)	0.556	3
UniProt:Q63HM9 PLCX3			0.556	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.556	3
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.556	3
UniProt:Q9BYQ0 KRTAP9-8	1	KRTAP9-8 [cytosol] (R-HSA-6809953)	0.556	3
UniProt:Q9BYQ6 KRTAP4-11	1	KRTAP4-11 [cytosol] (R-HSA-6809960)	0.556	3
IntAct:EBI-25846222 CCSB			0.556	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.556	3
UniProt:Q8WUG5 SLC22A17	1	SLC22A17 [plasma membrane] (R-HSA-561099)	0.556	3
UniProt:O43521 BCL2L11	7	BCL2L11 [mitochondrial outer membrane] (R-HSA-2976674) BCL2L11(1-131)-BRAF(397-766) fusion [cytosol] (R-HSA-6802276) BCL2L11(1-131)-p-BRAF(397-766) fusion [cytosol] (R-HSA-6802519) p-S69-BCL2L11 [cytosol] (R-HSA-2976671) p-BCL2L11 [mitochondrial outer membrane] (R-HSA-3145027) p-BCL2L11 [cytosol] (R-HSA-140525) BCL2L11 [cytosol] (R-HSA-2976673)	0.556	3
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.556	3
UniProt:Q7Z4N8 P4HA3	1	P4HA3 [endoplasmic reticulum lumen] (R-HSA-2980915)	0.527	2
UniProt:Q8N680 ZBTB2			0.527	2
UniProt:Q2GL86 Q2GL86			0.508	3
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.499	4
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.463	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

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