Reactome | ACD [nucleoplasm]

ACD [nucleoplasm]

Stable Identifier

R-HSA-174889

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

PTOP, TPP1

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Telomere shortening during replicative exhaustion (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        ACD [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        ACD [nucleoplasm] (Homo sapiens)

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        ACD [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        ACD [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96AP0 ACD

Gene Names

ACD, PIP1, PTOP, TINT1, TPP1

Chain

chain:1-458

Reference Genes

BioGPS Gene:65057 ACD

COSMIC (genes):ACD ACD

CTD Gene:65057 ACD

dbSNP Gene:65057 ACD

ENSEMBL:ENSG00000102977 ACD

ENSEMBL_homo_sapiens_GENE:ENSG00000102977.18 ACD

HGNC:25070 ACD

KEGG Gene (Homo sapiens):65057 ACD

Monarch:65057 ACD

NCBI Gene:65057 ACD

OMIM:609377 ACD

UCSC:Q96AP0 ACD

Reference Transcript

Other Identifiers

11718424_at

11748894_a_at

16827394

204617_PM_s_at

204617_s_at

3695791

3695792

3695794

3695796

3695798

3695800

3695803

3695804

3695806

3695808

3695810

3695812

3695814

3695816

3695817

3695818

37246_at

65057

8002057

A_23_P26375

A_33_P3359071

GE54627

GO:0000723

GO:0000781

GO:0000783

GO:0001501

GO:0001655

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005697

GO:0006886

GO:0007004

GO:0016233

GO:0016604

GO:0030326

GO:0031848

GO:0032200

GO:0032202

GO:0032206

GO:0032211

GO:0032212

GO:0035282

GO:0042162

GO:0043226

GO:0044877

GO:0048856

GO:0051973

GO:0060381

GO:0070182

GO:0070187

GO:0070198

GO:0070200

HMNXSV003037879

HMNXSV003049256

HMNXSV003057236

ILMN_1716480

PH_hs_0004505

TC16001193.hg

g12597658_3p_a_at

Participates

as a component of

Inferred To

Acd [nucleoplasm] (Mus musculus)

Acd [nucleoplasm] (Rattus norvegicus)

Ghost homologue of ACD [nucleoplasm] (Gallus gallus)

Ghost homologue of ACD [nucleoplasm] (Schizosaccharomyces pombe)

acd [nucleoplasm] (Xenopus tropicalis)

ACD [nucleoplasm] (Bos taurus)

ACD [nucleoplasm] (Canis familiaris)

ACD [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_001075955.1, NP_075065.2, NP_001075956.1

OpenTargets

ENSG00000102977

HPA

ENSG00000102977-ACD

GeneCards

Q96AP0

Ensembl

ENSP00000478084, ENST00000620761, ENST00000219251, ENSG00000102977, ENSP00000219251

PRO

Q96AP0

Pharos - Targets

Q96AP0

Orphanet

23097

PDB

5XYF, 7QXB, 7TRE, 2I46, 8SOJ, 5H65, 7S1T, 5I2X, 8SOK, 5UN7, 5I2Y, 7QXS, 7QXA

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NUX5 POT1	1	POT1 [nucleoplasm] (R-HSA-174890)	0.89	9
UniProt:Q91WC1 Pot1	2	Protection of telomeres protein 1 [nucleoplasm] (R-MMU-912386) Pot1 [nucleoplasm] (R-MMU-174890)	0.589	3
UniProt:Q93009 USP7	2	USP7 [cytosol] (R-HSA-8853511) USP7 [nucleoplasm] (R-HSA-3215278)	0.547	2
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.524	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.508	2
UniProt:Q9H477 RBKS	1	RBKS [cytosol] (R-HSA-8955847)	0.508	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.508	2
UniProt:P07476 IVL	2	IVL [cornified envelope] (R-HSA-8847720) IVL [cytosol] (R-HSA-6810837)	0.508	2
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.508	2
UniProt:Q9BXI6 TBC1D10A	2	TBC1D10A [cytosol] (R-HSA-8854139) TBC1D10A [microvillus] (R-HSA-8854143)	0.508	2
UniProt:O43768 ENSA	2	p-S67-ENSA [nucleoplasm] (R-HSA-2430532) ENSA [nucleoplasm] (R-HSA-2160964)	0.508	2
UniProt:Q9BTW9 TBCD	1	TBCD [cytosol] (R-HSA-379540)	0.508	2
UniProt:Q9UJU6 DBNL	7	DBNL [tertiary granule lumen] (R-HSA-6801516) DBNL [secretory granule lumen] (R-HSA-6801520) DBNL [cytosol] (R-HSA-202880) DBNL(362-431) [cytosol] (R-HSA-202933) DBNL(1-361) [cytosol] (R-HSA-202925) DBNL [ficolin-1-rich granule lumen] (R-HSA-6801510) DBNL [extracellular region] (R-HSA-6801604)	0.508	2
UniProt:Q9H668 STN1	1	STN1 [nucleoplasm] (R-HSA-9668821)	0.508	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.508	2

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