Reactome | POT1 [nucleoplasm]

POT1 [nucleoplasm]

Stable Identifier

R-HSA-174890

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Reproduction (Homo sapiens)

- Meiosis (Homo sapiens)
  - Meiotic synapsis (Homo sapiens)
    - Telomeres cluster at the nuclear membrane (Homo sapiens)
      - Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        POT1 [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        POT1 [nucleoplasm] (Homo sapiens)
      - Telomere Attachment Plate [nuclear envelope] (Homo sapiens)
        
        Extended And Processed Telomere End and Associated DNA Binding and Packaging Protein Complex Folded Into Higher Order Structure [nucleoplasm] (Homo sapiens)
        
        POT1 [nucleoplasm] (Homo sapiens)
        
        Shelterin complex [nucleoplasm] (Homo sapiens)
        
        POT1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NUX5 POT1

Gene Names

POT1

Chain

chain:1-634

Reference Genes

BioGPS Gene:25913 POT1

COSMIC (genes):POT1 POT1

CTD Gene:25913 POT1

dbSNP Gene:25913 POT1

ENSEMBL:ENSG00000128513 POT1

ENSEMBL_homo_sapiens_GENE:ENSG00000128513.16 POT1

HGNC:17284 POT1

KEGG Gene (Homo sapiens):25913 POT1

Monarch:25913 POT1

NCBI Gene:25913 POT1

OMIM:606478 POT1

UCSC:Q9NUX5 POT1

Reference Transcript

Other Identifiers

11733079_a_at

11733080_a_at

11741651_a_at

17062502

204353_PM_s_at

204353_s_at

204354_PM_at

204354_at

25913

3070909

3070910

3070911

3070912

3070913

3070914

3070916

3070917

3070918

3070919

3070921

3070922

3070923

3070925

3070928

3070929

3070930

3070933

3070934

3070935

3070936

3070937

3070938

3070939

3070940

3070943

3070944

3070945

3070946

3070947

39653_at

8142697

A_23_P84610

A_24_P309105

A_33_P3882624

GE55722

GE84567

GO:0000723

GO:0000781

GO:0000783

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0006281

GO:0007004

GO:0010521

GO:0016233

GO:0017151

GO:0032200

GO:0032202

GO:0032206

GO:0032210

GO:0032211

GO:0032212

GO:0032508

GO:0042162

GO:0043047

GO:0043226

GO:0051096

GO:0051973

GO:0051974

GO:0060383

GO:0061820

GO:0061821

GO:0070187

GO:0070200

GO:0098505

GO:0098772

GO:1905773

GO:1905774

GO:1905776

GO:1990955

GO:2001032

HMNXSV003021191

ILMN_1692041

ILMN_2327203

PH_hs_0002716

TC07001830.hg

TC07003148.hg

g12804138_3p_a_at

g13123773_3p_at

Participates

as a component of

as an input of

as an output of

Telomere shortening during replicative exhaustion (Homo sapiens)

Inferred To

Pot1 [nucleoplasm] (Mus musculus)

Pot1 [nucleoplasm] (Rattus norvegicus)

pot1 [nucleoplasm] (Schizosaccharomyces pombe)

pot1 [nucleoplasm] (Xenopus tropicalis)

POT1 [nucleoplasm] (Bos taurus)

POT1 [nucleoplasm] (Canis familiaris)

POT1 [nucleoplasm] (Gallus gallus)

POT1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

XP_006715980.1, NP_001036059.1, NP_056265.2

OpenTargets

ENSG00000128513

GeneCards

Q9NUX5

HPA

ENSG00000128513-POT1

ZINC target

Q9NUX5

Ensembl

ENST00000664366, ENST00000668382, ENST00000653241, ENST00000655761, ENSP00000350249, ENST00000357628, ENSG00000128513, ENSP00000499635, ENSP00000499476, ENSP00000499546, ENSP00000499290

PRO

Q9NUX5

Pharos - Targets

Q9NUX5

Orphanet

22138

PDB

8SH0, 8SOJ, 1XJV, 7QXS, 7S1U, 3KJP, 3KJO, 7S1T, 5H65, 8SH1, 5UN7, 7S1O, 8SOK, 7QXB

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96AP0 ACD	1	ACD [nucleoplasm] (R-HSA-174889)	0.921	11
UniProt:Q15554 TERF2	2	TERF2 [nucleoplasm] (R-HSA-174895) p-S365-TERF2 [nucleoplasm] (R-HSA-9686530)	0.886	10
UniProt:Q9BSI4 TINF2	1	TINF2 [nucleoplasm] (R-HSA-174883)	0.738	6
UniProt:Q9NYB0 TERF2IP	1	TERF2IP [nucleoplasm] (R-HSA-174873)	0.725	6
UniProt:Q9Y281 COF2			0.556	3
UniProt:Q549N0 Q549N0			0.556	3
UniProt:Q9BSI4-2 TINF2			0.527	2
UniProt:P54274 TERF1	1	TERF1 [nucleoplasm] (R-HSA-164618)	0.527	2
UniProt:P54274-2 TERF1			0.527	2
UniProt:P63313 TYB10			0.508	2
UniProt:Q99795 GPA33			0.508	2
UniProt:Q9BR01 SULT4A1	1	SULT4A1 [cytosol] (R-HSA-176668)	0.508	2
UniProt:Q9BY11 PACSIN1	1	PACSIN1 [cytosol] (R-HSA-8868269)	0.508	2
UniProt:Q9BRP8 PYM1			0.508	2
UniProt:P0DMV8 HSPA1A	4	HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496) HSPA1A [cytosol] (R-HSA-6792602)	0.508	2
UniProt:P30838 ALDH3A1	1	ALDH3A1 [cytosol] (R-HSA-5692291)	0.508	2
UniProt:Q01064 PDE1B	2	activated PDE1B [cytosol] (R-HSA-9014908) PDE1B [cytosol] (R-HSA-52371)	0.508	2
UniProt:Q96GU1 PAGE5			0.508	2
UniProt:Q8IUZ5 PHYKPL	1	PXLP-K278-PHYKPL [mitochondrial matrix] (R-HSA-5696428)	0.508	2
UniProt:P46952 HAAO	1	HAAO [cytosol] (R-HSA-71085)	0.508	2
UniProt:Q96A49 SYAP1			0.508	2
UniProt:Q5SRE7 PHYD1			0.508	2
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.508	2
UniProt:Q9BWH6 RPAP1			0.508	2
UniProt:Q03426 MVK	1	MVK [cytosol] (R-HSA-191375)	0.508	2
UniProt:O43704 SULT1B1	1	SULT1B1 [cytosol] (R-HSA-176551)	0.508	2
UniProt:Q6PJW8 CNST			0.508	2
UniProt:P50747 HLCS	8	HLCS [cytosol] (R-HSA-2993867) HLCS L216R [cytosol] (R-HSA-3325513) HLCS D571N [cytosol] (R-HSA-3325499) HLCS L237P [cytosol] (R-HSA-3325514) HLCS V550M [cytosol] (R-HSA-3325460) HLCS G261Vfs*20 [cytosol] (R-HSA-3325463) HLCS R508W [cytosol] (R-HSA-3325442) HLCS G581S [cytosol] (R-HSA-3325506)	0.508	2
UniProt:Q86WR7 PRSR2			0.508	2
UniProt:Q9NPH2 ISYNA1	1	ISYNA1 [cytosol] (R-HSA-1604599)	0.508	2
UniProt:Q9Y4P8 WIPI2	1	WIPI2 [cytosol] (R-HSA-5678305)	0.508	2
UniProt:O95833 CLIC3			0.508	2
UniProt:Q8WXG6 MADD			0.508	2
UniProt:Q9BV29 CCD32			0.508	2
UniProt:P43358 MAGA4			0.508	2
UniProt:O94808 GFPT2	1	GFPT2 [cytosol] (R-HSA-532208)	0.508	2
UniProt:Q96A73 P33MX			0.508	2
UniProt:Q12851 M4K2			0.508	2
UniProt:Q9P0Z9 PIPOX	2	PIPOX [cytosol] (R-HSA-9033136) PIPOX [peroxisomal matrix] (R-HSA-452911)	0.508	2
UniProt:P07355 ANXA2	6	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) p-S26-ANXA2 [cytosol] (R-HSA-9865163) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.508	2
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.508	2
UniProt:P05783 KRT18	1	KRT18 [cytosol] (R-HSA-201582)	0.488	2

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