Reactome | UGTs transfer GlcA from UDP-GlcA to O-centre substrates

UGTs transfer GlcA from UDP-GlcA to O-centre substrates

Stable Identifier

R-HSA-174931

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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UGTs transfer GlcA from UDP-GlcA to O-centre substrates

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Typical O-centred substrates were chosen as examples for these isozymes. Many UDP-glucuronosyltransferases (UGTs) can transfer the glucuronyl moiety (GlcA) from UDP-GlcA to the O-centre functional group of many substrates, including salicylate (ST), to form 4-O-glucuronides (Casarett & Doull 1995, Babu et al. 1996; Kuehl et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
16258079	Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes Kuehl, GE, Potter, JD, Lampe, JW, Bigler, J	Drug Metab Dispos	2006
	Casarett and Doull's Toxicology 5th Edn Parkinson, A		1995
8687483	Glucuronide conjugates of 4-aminobiphenyl and its N-hydroxy metabolites. pH stability and synthesis by human and dog liver. Davis, BB, Lakshmi, VM, Huang, GP, Babu, SR, Zenser, TV	Biochem Pharmacol	1996