1-LTR circle formation

Stable Identifier
R-HSA-175117
Type
Reaction [dissociation]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
Compartment
nucleoplasm
ReviewStatus
5/5
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1-LTR circle formation
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The 1-LTR circle can be formed by either of two pathways. The first involves a failure to complete reverse transcription; the second, annotated here, follows the completion of reverse transcription and is mediated by cellular enzymes. In this pathway, the action of host cell homologous recombination enzymes on the long terminal repeat (LTR) termini of the viral DNA results in formation of a single LTR. This reaction probably takes place after partial or complete disassembly of the PIC to expose the viral DNA. Repair of this intermediate as in the late stages of homologous recombination pathways results in formation of the 1-LTR circle. Mutations in the Mre11/Rad50/NBS pathway influence the formation of 1-LTR circles.
Literature References
PubMed ID Title Journal Year
16291214 Retroviral DNA integration--mechanism and consequences

Lewinski, MK, Bushman, FD

Adv Genet 2005
16175173 Genome-wide analysis of retroviral DNA integration

Lewinski, M, Ciuffi, A, Barr, S, Leipzig, J, Hannenhalli, S, Hoffmann, C, Bushman, FD

Nat Rev Microbiol 2005
  Retroviruses

Coffin, JM, Hughes, SH, Varmus, HE

  1997
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
Mondo
Authored
Gopinathrao, G  (2006-05-19)
D'Eustachio, P  (2006-05-19)
Reviewed
Bushman, FD  (2006-10-31)
Created
Gopinathrao, G  (2006-02-24)
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