Reactome | Interactions of Tat with host cellular proteins

Stable Identifier

R-HSA-176034

Type

Pathway

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The elongation of HIV-1 mRNA depends upon the interaction of Tat with the host P-TEFb complex (Hermann and Rice, 1995; Wei et al., 1998).

Literature References

PubMed ID	Title	Journal	Year
9491887	A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA Wei, P, Garber, ME, Fang, SM, Fischer, WH, Jones, KA	Cell	1998
7853496	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor Herrmann, CH, Rice, AP	J Virol	1995

Participants

Events

Participant Of

hasEvent

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	526	HIV infection

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Gopinathrao, G (2006-03-01)

Cite Us!