Reactome | Interactions of Tat with host cellular proteins

Stable Identifier

R-HSA-176034

Type

Pathway

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

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The elongation of HIV-1 mRNA depends upon the interaction of Tat with the host P-TEFb complex (Hermann and Rice, 1995; Wei et al., 1998).

Literature References

PubMed ID	Title	Journal	Year
7853496	Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor Rice, AP, Herrmann, CH	J Virol	1995
9491887	A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA Wei, P, Jones, KA, Fang, SM, Fischer, WH, Garber, ME	Cell	1998

Participants

Events

Participates

as an event of

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Gopinathrao, G (2006-03-01)

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