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Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Stable Identifier
R-HSA-176407
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Homo sapiens)
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The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1 (reviewed in Castro et al, 2005).
Literature References
PubMed ID
Title
Journal
Year
15678131
The anaphase-promoting complex: a key factor in the regulation of cell cycle
Lorca, T
,
Bernis, C
,
Vigneron, S
,
Castro, A
,
Labbe, JC
Oncogene
2005
Participants
Events
Dephosphorylation of phospho-Cdh1
(Homo sapiens)
Dissociation of Cdc20 from APC/C complex
(Homo sapiens)
Association of Cdh1 with the APC/C
(Homo sapiens)
Participates
as an event of
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Event Information
Go Biological Process
anaphase-promoting complex-dependent catabolic process (0031145)
Orthologous Events
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Bos taurus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Canis familiaris)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Danio rerio)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Dictyostelium discoideum)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Drosophila melanogaster)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Gallus gallus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Mus musculus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Rattus norvegicus)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Saccharomyces cerevisiae)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Schizosaccharomyces pombe)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Sus scrofa)
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000187
,
BIOMD0000000186
Authored
Castro, A (2006-01-26)
Lorca, T (2006-01-26)
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-03-08)
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