Regulation of APC/C activators between G1/S and early anaphase

Stable Identifier
R-HSA-176408
Type
Pathway
Species
Homo sapiens
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The APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zachariae and Nasmyth, 1999). Cdc20, whose protein levels increase as cells enter into mitosis and decrease upon mitotic exit, only associates with the APC/C during M phase. Cdh1 associates with the APC/C in G1. This interaction is inhibited at other times by Cdk1 phosphorylation.

Literature References
PubMed ID Title Journal Year
12049731 The anaphase-promoting complex: proteolysis in mitosis and beyond

Peters, JM

Mol Cell 2002
16508672 How APC/C orders destruction

Buschhorn, BA, Peters, JM

Nat Cell Biol 2006
15678131 The anaphase-promoting complex: a key factor in the regulation of cell cycle

Castro, A, Bernis, C, Vigneron, S, Labbe, JC, Lorca, T

Oncogene 2005
12208841 The anaphase-promoting complex: it's not just for mitosis any more.

Harper, JW, Burton, JL, Solomon, MJ

Genes Dev 2002
Participants
Participant Of
Orthologous Events
Cross References
Reviewed
Created