Reactome | APC/C:Cdc20 mediated degradation of mitotic proteins

APC/C:Cdc20 mediated degradation of mitotic proteins

Stable Identifier

R-HSA-176409

Type

Pathway

Species

Homo sapiens

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APC/C:Cdc20 mediated degradation of mitotic proteins

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Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)

Literature References

PubMed ID	Title	Journal	Year
10465783	Whose end is destruction: cell division and the anaphase-promoting complex. Zachariae, W, Nasmyth, K	Genes Dev	1999
15949434	The D box asserts itself Owens, TJ, Hoyt, MA	Mol Cell	2005