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APC/C:Cdc20 mediated degradation of mitotic proteins
Stable Identifier
R-HSA-176409
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
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Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)
Literature References
PubMed ID
Title
Journal
Year
15949434
The D box asserts itself
Hoyt, MA
,
Owens, TJ
Mol Cell
2005
10465783
Whose end is destruction: cell division and the anaphase-promoting complex.
Nasmyth, K
,
Zachariae, W
Genes Dev
1999
Participants
Events
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(Homo sapiens)
Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1
(Homo sapiens)
APC/C:Cdc20 mediated degradation of Cyclin B
(Homo sapiens)
APC/C:Cdc20 mediated degradation of Securin
(Homo sapiens)
Participates
as an event of
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
Event Information
Go Biological Process
regulation of exit from mitosis (0007096)
Orthologous Events
APC/C:Cdc20 mediated degradation of mitotic proteins (Bos taurus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Canis familiaris)
APC/C:Cdc20 mediated degradation of mitotic proteins (Dictyostelium discoideum)
APC/C:Cdc20 mediated degradation of mitotic proteins (Drosophila melanogaster)
APC/C:Cdc20 mediated degradation of mitotic proteins (Gallus gallus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Mus musculus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Rattus norvegicus)
APC/C:Cdc20 mediated degradation of mitotic proteins (Sus scrofa)
APC/C:Cdc20 mediated degradation of mitotic proteins (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000193
,
BIOMD0000000194
,
BIOMD0000000187
,
BIOMD0000000293
,
BIOMD0000000723
,
BIOMD0000000220
,
BIOMD0000000939
,
BIOMD0000000186
Reviewed
Peters, JM (2006-03-28)
Created
Matthews, L (2006-03-08)
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