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Orc2 associated with MCM8 [nucleoplasm]
Stable Identifier
R-HSA-176970
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
Activation of ATR in response to replication stress (Homo sapiens)
Activation of claspin (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Loading of claspin onto DNA during replication origin firing (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
E2F mediated regulation of DNA replication (Homo sapiens)
E2F-enabled inhibition of pre-replication complex formation (Homo sapiens)
Association of Cyclin B/Cdk1 with replicative origin inhibits pre-RC formation (Homo sapiens)
Cyclin B:CDK1:ORC:origin of replication [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Activation of the pre-replicative complex (Homo sapiens)
CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA polymerase alpha:primase binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
DNA polymerase epsilon binds at the origin (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
active pre-replicative complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Synthesis of DNA (Homo sapiens)
Switching of origins to a post-replicative state (Homo sapiens)
Orc1 removal from chromatin (Homo sapiens)
Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
pre-replicative complex [nucleoplasm] (Homo sapiens)
CDT1:CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
CDC6:ORC:origin complex [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Orc2 associated with MCM8 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
15684404
Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin
Hoffmann, I
,
Volkening, M
Mol Cell Biol
2005
Participants
components
MCM8 [nucleoplasm]
(Homo sapiens)
ORC2 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
ORC:origin of replication [nucleoplasm] (Homo sapiens)
Inferred To
Orc2 associated with MCM8 [nucleoplasm]
(Bos taurus)
Orc2 associated with MCM8 [nucleoplasm]
(Caenorhabditis elegans)
Orc2 associated with MCM8 [nucleoplasm]
(Canis familiaris)
Orc2 associated with MCM8 [nucleoplasm]
(Dictyostelium discoideum)
Orc2 associated with MCM8 [nucleoplasm]
(Drosophila melanogaster)
Orc2 associated with MCM8 [nucleoplasm]
(Gallus gallus)
Orc2 associated with MCM8 [nucleoplasm]
(Mus musculus)
Orc2 associated with MCM8 [nucleoplasm]
(Rattus norvegicus)
Orc2 associated with MCM8 [nucleoplasm]
(Saccharomyces cerevisiae)
Orc2 associated with MCM8 [nucleoplasm]
(Schizosaccharomyces pombe)
Orc2 associated with MCM8 [nucleoplasm]
(Sus scrofa)
Orc2 associated with MCM8 [nucleoplasm]
(Xenopus tropicalis)
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