Unwinding of DNA

Stable Identifier
R-HSA-176974
Type
Pathway
Species
Homo sapiens
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DNA Replication is regulated accurately and precisely by various protein complexes. Many members of the MCM protein family are assembled into the pre-Replication Complexes (pre-RC) at the end of M phase of the cell cycle. DNA helicase activity of some of the MCM family proteins are important for the unwinding of DNA and initiation of replication processes. This section contains four events which have been proved in different eukaryotic experimental systems to involve various proteins for this essential step during DNA Replication.

Literature References
PubMed ID Title Journal Year
10834843 Uninterrupted MCM2-7 function required for DNA replication fork progression.

Labib, K, Tercero, JA, Diffley, JF

Science 2000
15707891 MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation

Maiorano, D, Cuvier, O, Danis, E, Mechali, M

Cell 2005
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