Conjugation of salicylate with glycine

Stable Identifier
R-HSA-177128
Type
Pathway
Species
Homo sapiens
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Summation

In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylic acid. Salicylic acid (2-hydroxybenzoic acid) can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here, and proceeds in two steps. First, salicylate and ATP react with coenzyme A to form salicylate CoA, AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, salicylate CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994).

Literature References
PubMed ID Title Journal Year
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Vessey, DA, Lau, E, Kelley, M, Warren, RS

J Biochem Mol Toxicol 2003
7802672 Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver

Mawal, YR, Qureshi, IA

Biochem Biophys Res Commun 1994
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