Reactome | Conjugation of salicylate with glycine

Conjugation of salicylate with glycine

Stable Identifier

R-HSA-177128

Type

Pathway

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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In the body, aspirin (acetylsalicylic acid) is hydrolyzed to salicylate (ST). ST can then be hydroxylated to yield gentisic acid, conjugated with glucuronate, or conjugated with glycine to yield molecules that are excreted by the kidneys. The third of these conjugation processes is annotated here. It is the major route of ST catabolism and accounts for 20–65% of the products (Hutt et al, 1986). The conjugation proceeds in two steps. First, ST and ATP react with coenzyme A to form salicylate-CoA (ST-CoA), AMP, and pyrophosphate in a reaction catalyzed by xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Second, ST-CoA and glycine react to form salicyluric acid and Coenzyme A (Mawal and Qureshi 1994).

Literature References

PubMed ID	Title	Journal	Year
7802672	Purification to homogeneity of mitochondrial acyl coa:glycine n-acyltransferase from human liver Qureshi, IA, Mawal, YR	Biochem Biophys Res Commun	1994
12616642	Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria Kelley, M, Warren, RS, Lau, E, Vessey, DA	J Biochem Mol Toxicol	2003
3705620	The metabolism of aspirin in man: a population study Smith, RL, Caldwell, J, Hutt, AJ	Xenobiotica	1986