phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate

Stable Identifier
R-HSA-177157
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Synthesis of phenylacetyl CoA from phenylacetate and Coenzyme A
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Phenylacetate and ATP react with coenzyme A to form phenylacetyl CoA, AMP, and pyrophosphate (Vessey et al. 1999). Two human CoA ligases have been characterized that catalyze this reaction efficiently in vitro: acyl-CoA synthetase medium-chain family member 1 (BUCS1) (Fujino et al. 2001) and xenobiotic/medium-chain fatty acid:CoA ligase (Vessey et al. 2003). Their relative contributions to phenylacetate metabolism in vivo are unknown.

Literature References
PubMed ID Title Journal Year
12616642 Isolation, sequencing, and expression of a cDNA for the HXM-A form of xenobiotic/medium-chain fatty acid:CoA ligase from human liver mitochondria

Vessey, DA, Lau, E, Kelley, M, Warren, RS

J Biochem Mol Toxicol 2003
11470804 Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product

Fujino, T, Takei, YA, Sone, H, Ioka, RX, Kamataki, A, Magoori, K, Takahashi, S, Sakai, J, Yamamoto, TT

J Biol Chem 2001
10434065 Characterization of the CoA ligases of human liver mitochondria catalyzing the activation of short- and medium-chain fatty acids and xenobiotic carboxylic acids

Vessey, DA, Kelley, M, Warren, RS

Biochim Biophys Acta 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
CoA-ligase activity of xenobiotic/medium-chain fatty acid:CoA ligases [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Reviewed
Created