PKA phosphorylates DARPP-32 on Thr34

Stable Identifier
R-HSA-177275
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DARPP-32 is phosphorylated by cAMP-dependent protein kinase (PKA) on a single threonine residue, Thr34, resulting in its conversion into a potent inhibitor of protein phosphatase-1.

Literature References
PubMed ID Title Journal Year
6296685 A dopamine- and cyclic AMP-regulated phosphoprotein enriched in dopamine-innervated brain regions.

Walaas, SI, Aswad, DW, Greengard, P

Nature 1983
6501302 DARPP-32, a dopamine- and adenosine 3':5'-monophosphate-regulated neuronal phosphoprotein. I. Amino acid sequence around the phosphorylated threonine

Hemmings HC, Jr, Williams, KR, Konigsberg, WH, Greengard, P

J Biol Chem 1984
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cAMP-dependent protein kinase activity of PKA catalytic subunit [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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Created