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NFKB1(1-433) [nucleoplasm]
Stable Identifier
R-HSA-177655
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NFkB1 p50, Nuclear factor NF-kappa-B p50 subunit
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Homo sapiens)
p-S536-RELA:NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
Regulation of NFE2L2 gene expression (Homo sapiens)
NFkB binds the NFE2L2 gene (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFkB dependent NFE2L2 expression (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD6 methylates RELA in the NFkB complex (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFkB Complex with MeK310-RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of PPARG (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Immediate Early (IE) Gene Expression (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Regulation of PD-L1(CD274) expression (Homo sapiens)
Regulation of PD-L1(CD274) transcription (Homo sapiens)
CD274 Transcription (Homo sapiens)
NFKB_Complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB_Complex:CD274 gene [nucleoplasm] (Homo sapiens)
NFKB_Complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB_complex binding to CD274 gene (Homo sapiens)
NFKB_Complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB_Complex:CD274 gene [nucleoplasm] (Homo sapiens)
NFKB_Complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] (Homo sapiens)
NF-kappaB p50:c-Rel [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NF-kappaB p50:p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
CBP and p300 binds NF-kB complex (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
p300 acetylates RELA subunit (Homo sapiens)
NFKB1:p-S276,5AcK-RELA:p300/CBP [nucleoplasm] (Homo sapiens)
NFKB1:p-S276,5AcK-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA:p300/CBP [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
IL1B gene is transcribed (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19838 NFKB1
Gene Names
NFKB1
Chain
chain:1-968, chain:1-433
Reference Genes
BioGPS Gene:4790 NFKB1
COSMIC (genes):NFKB1 NFKB1
CTD Gene:4790 NFKB1
dbSNP Gene:4790 NFKB1
ENSEMBL:ENSG00000109320 NFKB1
HGNC:7794 NFKB1
KEGG:hsa:4790 NFKB1
Monarch:4790 NFKB1
NCBI Gene:4790 NFKB1
OMIM:164011 NFKB1
UCSC:P19838 NFKB1
Reference Transcript
RefSeq:NM_001382625.1 NFKB1
RefSeq:XM_047415742.1 NFKB1
RefSeq:NM_001382627.1 NFKB1
RefSeq:XM_024454068.1 NFKB1
RefSeq:XM_054350115.1 NFKB1
RefSeq:NM_001319226.2 NFKB1
RefSeq:NM_001165412.2 NFKB1
RefSeq:NM_001382626.1 NFKB1
RefSeq:XM_054350114.1 NFKB1
RefSeq:NM_003998.3 NFKB1
Participates
as a component of
p-S536-RELA:NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NF-kappaB p50:c-Rel [nucleoplasm] (Homo sapiens)
NF-kappaB p50:p50 [nucleoplasm] (Homo sapiens)
NFKB1:p-S276,5AcK-RELA [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
as a member of
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Immediate Early (IE) Gene Expression
(Homo sapiens)
Other forms of this molecule
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
p-S927,S932-NFKB1(1-968) [cytosol]
NFKB1(1-968) [cytosol]
NFKB1(1-433) [cytosol]
NFKB1(1-968) [specific granule lumen]
NFKB1(1-968) [extracellular region]
NFKB1(1-968) [secretory granule lumen]
Inferred To
Nfkb1 [nucleoplasm]
(Mus musculus)
Nfkb1 [nucleoplasm]
(Rattus norvegicus)
Rel [nucleoplasm]
(Drosophila melanogaster)
NFKB1 [nucleoplasm]
(Bos taurus)
NFKB1 [nucleoplasm]
(Gallus gallus)
NFKB1 [nucleoplasm]
(Sus scrofa)
nfkb1 [nucleoplasm]
(Danio rerio)
nfkb1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
XP_047271698.1
,
XP_024309836.1
,
NP_001369554.1
,
NP_001369556.1
,
NP_001158884.1
,
NP_001369555.1
,
XP_054206089.1
,
NP_001306155.1
,
NP_003989.2
,
XP_054206090.1
Guide to Pharmacology - Targets
3281
OpenTargets
ENSG00000109320
ENSEMBL
ENSP00000378297
,
ENST00000226574
,
ENSP00000424790
,
ENST00000394820
,
ENST00000509165
,
ENSG00000109320
,
ENST00000505458
,
ENSP00000423877
,
ENSP00000226574
ZINC - Substances
NFKB1_HUMAN
ZINC - Biogenic
NFKB1_HUMAN
ZINC target
P19838
PRO
P19838
GlyGen
P19838
PDB
7RG5
,
7RG4
,
7LF4
,
2O61
,
2DBF
,
1SVC
,
8TQD
,
3GUT
,
1MDI
,
1MDK
,
1MDJ
,
7LEQ
,
1NFI
,
7LET
,
7LFC
ZINC - Metabolites
NFKB1_HUMAN
GeneCards
NFKB1
HPA
ENSG00000109320-NFKB1
Pharos - Targets
P19838
Orphanet
NFKB1
ZINC - Predictions - Purchasable
NFKB1_HUMAN
HMDB Protein
HMDBP02145
Interactors (40)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25963 NFKBIA
9
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.933
11
UniProt:P41279 MAP3K8
3
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
0.927
14
UniProt:Q04206 RELA
7
RELA [nucleoplasm]
(R-HSA-177676)
RELA [cytosol]
(R-HSA-168172)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
0.924
16
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.865
8
UniProt:Q00653 NFKB2
6
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
p-7S-p100 [cytosol]
(R-HSA-5607629)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
0.823
10
UniProt:Q15653 NFKBIB
3
NFKBIB [cytosol]
(R-HSA-168132)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
0.816
7
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.816
10
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.788
7
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.779
4
UniProt:O14920 IKBKB
3
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
0.773
4
UniProt:P19838 NFKB1
8
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
0.764
7
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.744
7
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.695
4
UniProt:Q9UKB1 FBXW11
2
FBXW11 [cytosol]
(R-HSA-976035)
FBXW11 [nucleoplasm]
(R-HSA-9953055)
0.69
6
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.689
7
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.689
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
0.646
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.646
5
UniProt:P23396 RPS3
2
RPS3 [cytosol]
(R-HSA-72369)
RPS3 [nucleoplasm]
(R-HSA-6798714)
0.623
5
IntAct:EBI-9870239 IKK
0.623
2
UniProt:Q9Y6K9 IKBKG
12
IKBKG [cytosol]
(R-HSA-168108)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
IKBKG [nucleoplasm]
(R-HSA-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
0.615
3
UniProt:O00221 NFKBIE
3
NFKBIE [cytosol]
(R-HSA-1168580)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
0.604
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.597
5
UniProt:P29590 PML
5
PML [cytosol]
(R-HSA-5624327)
PML [nucleoplasm]
(R-HSA-1031706)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
0.589
3
UniProt:Q92905 COPS5
3
CSN5 [cytosol]
(R-HSA-9929354)
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.547
2
UniProt:P14921 ETS1
2
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
ETS1 [nucleoplasm]
(R-HSA-1629809)
0.536
2
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.527
2
UniProt:P12273 PIP
1
PIP [extracellular region]
(R-HSA-5252061)
0.527
2
UniProt:O14965 AURKA
6
p-T288-AURKA [cytosol]
(R-HSA-2574832)
AURKA [cytosol]
(R-HSA-174254)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
0.527
3
UniProt:Q13426 XRCC4
2
XRCC4 [nucleoplasm]
(R-HSA-75911)
monoSUMO1-K210-XRCC4 [nucleoplasm]
(R-HSA-4568892)
0.527
3
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.527
2
UniProt:P10226 PAP
0.524
4
UniProt:Q8IV08 PLD3
2
PLD3 [plasma membrane]
(R-HSA-2029042)
PLD3 [endoplasmic reticulum membrane]
(R-HSA-1498798)
0.524
2
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.524
2
UniProt:Q14690 PDCD11
1
PDCD11 [nucleoplasm]
(R-HSA-6790646)
0.508
2
UniProt:Q92887 ABCC2
5
ABCC2 [plasma membrane]
(R-HSA-375571)
ABCC2 I1173F [plasma membrane]
(R-HSA-5679030)
ABCC2 R1150H [plasma membrane]
(R-HSA-5679024)
ABCC2 R1066* [plasma membrane]
(R-HSA-5679021)
ABCC2 R768W [plasma membrane]
(R-HSA-5679033)
0.508
3
UniProt:P34931 HSPA1L
2
HSPA1L [nucleoplasm]
(R-HSA-5082367)
HSPA1L [cytosol]
(R-HSA-3371410)
0.483
3
UniProt:Q9BQI6 SLF1
0.483
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.483
3
UniProt:P08563-PRO_0000041302
0.463
2
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