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NFKB1(1-433) [nucleoplasm]
Stable Identifier
R-HSA-177655
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NFkB1 p50, Nuclear factor NF-kappa-B p50 subunit
Icon
Locations in the PathwayBrowser for interactor UniProt:P25963 NFKBIA
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
HCMV Infection (Homo sapiens)
HCMV Early Events (Homo sapiens)
Immediate Early (IE) Gene Expression (Homo sapiens)
NFKB1(1-433) [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P19838 NFKB1
Gene Names
NFKB1
Chain
chain:1-968, chain:1-433
Reference Genes
BioGPS Gene:4790 NFKB1
COSMIC (genes):NFKB1 NFKB1
CTD Gene:4790 NFKB1
dbSNP Gene:4790 NFKB1
ENSEMBL:ENSG00000109320 NFKB1
ENSEMBL_homo_sapiens_GENE:ENSG00000109320.14 NFKB1
HGNC:7794 NFKB1
KEGG Gene (Homo sapiens):4790 NFKB1
Monarch:4790 NFKB1
NCBI Gene:4790 NFKB1
OMIM:164011 NFKB1
UCSC:P19838 NFKB1
Reference Transcript
RefSeq:NM_001319226.1 NFKB1
RefSeq:NM_001165412.1 NFKB1
RefSeq:NM_003998.3 NFKB1
Other Identifiers
11717542_a_at
1377_at
1378_g_at
16969300
209239_PM_at
209239_at
2737731
2737732
2737737
2737740
2737743
2737745
2737753
2737756
2737759
2737762
2737763
2737765
2737770
2737771
2737772
2737773
2737775
2737776
2737781
2737783
2737784
2737789
2737790
2737791
2737793
2737796
2737797
38438_at
4790
8096635
A_14_P115699
A_23_P30024
GE57992
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001818
GO:0002376
GO:0003677
GO:0003682
GO:0003700
GO:0003712
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006629
GO:0006766
GO:0006915
GO:0006954
GO:0007165
GO:0007249
GO:0007254
GO:0008092
GO:0010467
GO:0010468
GO:0010629
GO:0010744
GO:0010884
GO:0010956
GO:0010957
GO:0012501
GO:0023052
GO:0030154
GO:0031410
GO:0032375
GO:0032695
GO:0033256
GO:0034097
GO:0034774
GO:0035525
GO:0035580
GO:0035994
GO:0038061
GO:0042802
GO:0042805
GO:0043066
GO:0043226
GO:0043565
GO:0045087
GO:0045892
GO:0045893
GO:0045944
GO:0048856
GO:0050728
GO:0050853
GO:0051248
GO:0060056
GO:0060261
GO:0071222
GO:0071260
GO:0071316
GO:0071347
GO:0071354
GO:0071356
GO:0071359
GO:0090263
GO:0097398
GO:0098542
GO:0098586
GO:0140110
GO:0140367
GO:1900127
GO:1901135
GO:1904385
GO:2000630
HMNXSV003038926
ILMN_1714965
M58603_at
PH_hs_0022751
TC04000526.hg
g189179_3p_at
Participates
as a component of
p-S536-RELA:NFKB1(1-433) [nucleoplasm] (Homo sapiens)
NFKB1:p-S276,5AcK-RELA [nucleoplasm] (Homo sapiens)
NFKB1:p-S276-RELA [nucleoplasm] (Homo sapiens)
NF-kappaB p50:c-Rel [nucleoplasm] (Homo sapiens)
NF-kappaB p50:p50 [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
as a member of
Nuclear factor NF-kappa-B p50 [nucleoplasm] (Homo sapiens)
This entity regulates
Positively
Immediate Early (IE) Gene Expression
(Homo sapiens)
Other forms of this molecule
NFKB1(1-968) [specific granule lumen]
NFKB1(1-968) [extracellular region]
NFKB1(1-968) [secretory granule lumen]
NFKB1(1-433) [cytosol]
NFKB1(1-968) [cytosol]
p-S927,S932-NFKB1(1-968) [cytosol]
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
Inferred To
Nfkb1 [nucleoplasm]
(Mus musculus)
Rel [nucleoplasm]
(Drosophila melanogaster)
NFKB1 [nucleoplasm]
(Bos taurus)
NFKB1 [nucleoplasm]
(Canis familiaris)
NFKB1 [nucleoplasm]
(Gallus gallus)
NFKB1 [nucleoplasm]
(Sus scrofa)
nfkb1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001158884.1
,
NP_001306155.1
,
NP_003989.2
Guide to Pharmacology - Targets
3281
OpenTargets
ENSG00000109320
ZINC - Substances
NFKB1_HUMAN
ZINC - Biogenic
NFKB1_HUMAN
ZINC target
P19838
PRO
P19838
PDB
1MDJ
,
8TQD
,
7LEQ
,
7LF4
,
7LFC
,
1SVC
,
2O61
,
7RG5
,
1NFI
,
7LET
,
1MDI
,
1MDK
,
2DBF
,
3GUT
,
7RG4
ZINC - Metabolites
NFKB1_HUMAN
HPA
ENSG00000109320-NFKB1
GeneCards
P19838
Ensembl
ENSP00000423877
,
ENST00000394820
,
ENST00000226574
,
ENSP00000378297
,
ENSP00000226574
,
ENSG00000109320
,
ENST00000505458
,
ENST00000509165
,
ENSP00000424790
Pharos - Targets
P19838
Orphanet
23358
ZINC - Predictions - Purchasable
NFKB1_HUMAN
HMDB Protein
HMDBP02145
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.933
11
UniProt:P41279 MAP3K8
3
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
0.927
14
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.924
16
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.865
8
UniProt:Q00653 NFKB2
6
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
(R-HSA-4755500)
NFKB2(1-900) [cytosol]
(R-HSA-2677931)
K48-polyUb-p-7S-p100 [cytosol]
(R-HSA-5607636)
p-7S-p100 [cytosol]
(R-HSA-5607629)
NFKB2(1-454) [cytosol]
(R-HSA-168144)
NFKB2(1-454) [nucleoplasm]
(R-HSA-177674)
0.823
10
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.816
10
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.779
4
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.773
4
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.764
7
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.763
6
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.744
7
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.725
6
UniProt:O60271 SPAG9
1
SPAG9 [cytosol]
(R-HSA-375975)
0.695
4
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.689
5
UniProt:Q8NFZ5 TNIP2
1
TNIP2 [cytosol]
(R-HSA-451661)
0.689
7
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.646
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.646
3
IntAct:EBI-9870239 IKK
0.623
2
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.623
5
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.615
3
UniProt:O00221 NFKBIE
3
NFKBIE [cytosol]
(R-HSA-1168580)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
0.604
3
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.597
5
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.597
5
UniProt:Q92905 COPS5
2
COPS5 [nucleoplasm]
(R-HSA-5697019)
COPS5 [cytosol]
(R-HSA-416963)
0.547
2
UniProt:P14921 ETS1
2
ETS1 [nucleoplasm]
(R-HSA-1629809)
p-T38-ETS1 [nucleoplasm]
(R-HSA-3132720)
0.536
2
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.527
2
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.527
3
UniProt:P10226 PAP
0.524
4
UniProt:Q8IV08 PLD3
2
PLD3 [endoplasmic reticulum membrane]
(R-HSA-1498798)
PLD3 [plasma membrane]
(R-HSA-2029042)
0.524
2
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.524
2
UniProt:Q14690 PDCD11
1
PDCD11 [nucleoplasm]
(R-HSA-6790646)
0.508
2
UniProt:Q92887 ABCC2
5
ABCC2 R768W [plasma membrane]
(R-HSA-5679033)
ABCC2 R1066* [plasma membrane]
(R-HSA-5679021)
ABCC2 R1150H [plasma membrane]
(R-HSA-5679024)
ABCC2 I1173F [plasma membrane]
(R-HSA-5679030)
ABCC2 [plasma membrane]
(R-HSA-375571)
0.508
3
UniProt:P34931 HSPA1L
2
HSPA1L [cytosol]
(R-HSA-3371410)
HSPA1L [nucleoplasm]
(R-HSA-5082367)
0.483
3
UniProt:Q9BQI6 SLF1
0.483
2
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.483
3
UniProt:P08563-PRO_0000041302
0.463
2
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