Reactome | Dimerized phospho-IRF3/IRF7 is transported to the nucleus

Dimerized phospho-IRF3/IRF7 is transported to the nucleus

Stable Identifier

R-HSA-177671

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, nuclear envelope, nucleoplasm

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TICAM1-dependent activation of IRF3/IRF7 (Homo sapiens)
        
        Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (Homo sapiens)
        
        Dimerized phospho-IRF3/IRF7 is transported to the nucleus (Homo sapiens)

General

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Dimerized phospho-IRF3/IRF7 is transported to the nucleus

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

IRF3-P:IRF3-P' is translocated from cytosol to nucleoplasm.

Literature References

PubMed ID	Title	Journal	Year
12692549	IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T	Nat Immunol	2003