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RELA [nucleoplasm]
Stable Identifier
R-HSA-177676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NFkB3, Nuclear factor NF-kappa-B p65 subunit, Transcription factor p65
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Activated CEBPB and NFKB complex bind IL8 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
Regulation of NFE2L2 gene expression (Homo sapiens)
NFkB binds the NFE2L2 gene (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFkB dependent NFE2L2 expression (Homo sapiens)
NFE2L2 gene:NFkB complex [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
SETD6 methylates RELA in the NFkB complex (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of PPARG (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Cell recruitment (pro-inflammatory response) (Homo sapiens)
Purinergic signaling in leishmaniasis infection (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Activated CEBPB and NFKB complex bind IL6 promoter (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
NF-kappaB translocates from the cytosol to the nucleus (Homo sapiens)
NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] (Homo sapiens)
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 processing (Homo sapiens)
Interleukin-1 family precursors are cleaved by caspase-1 (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CD209 (DC-SIGN) signaling (Homo sapiens)
Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A/inflammasome pathway (Homo sapiens)
IL1B gene is transcribed (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
DEx/H-box helicases activate type I IFN and inflammatory cytokines production (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
NFkB complex translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
NFKB1:RELA translocates from the cytosol to the nucleus (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
Inflammasomes (Homo sapiens)
The NLRP3 inflammasome (Homo sapiens)
Expression of NLRP3 gene (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
NF-kappa-B complex is transported from cytosol to nucleus (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of immune response proteins (Homo sapiens)
PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
RELA:RELA:DNA [nucleoplasm] (Homo sapiens)
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
NF-kB migrates to the nucleus and turns on transcription (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
RELA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04206 RELA
Gene Names
RELA, NFKB3
Chain
chain:1-551
Reference Genes
BioGPS Gene:5970 RELA
COSMIC (genes):RELA RELA
CTD Gene:5970 RELA
dbSNP Gene:5970 RELA
ENSEMBL:ENSG00000173039 RELA
ENSEMBL_homo_sapiens_GENE:ENSG00000173039.20 RELA
HGNC:9955 RELA
KEGG Gene (Homo sapiens):5970 RELA
Monarch:5970 RELA
NCBI Gene:5970 RELA
OMIM:164014 RELA
UCSC:Q04206 RELA
Reference Transcript
RefSeq:NM_021975.3 RELA
RefSeq:NM_001145138.1 RELA
RefSeq:NM_001243984.1 RELA
Other Identifiers
1045_s_at
11718104_x_at
11745440_s_at
1271_g_at
1295_at
16740495
201783_PM_s_at
201783_s_at
209878_PM_s_at
209878_s_at
3021614
3377790
3377791
3377792
3377793
3377794
3377795
3377796
3377799
3377800
3377802
3377803
3377805
3377806
3377807
3377810
3377811
3377812
3377814
3377817
36645_at
5970
7949465
A_23_P104689
A_24_P937256
A_33_P3209433
GE61225
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000979
GO:0000981
GO:0001223
GO:0001227
GO:0001228
GO:0001889
GO:0001942
GO:0002357
GO:0002376
GO:0002931
GO:0003677
GO:0003682
GO:0003690
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006117
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006952
GO:0006954
GO:0006968
GO:0007155
GO:0007218
GO:0007249
GO:0008092
GO:0008284
GO:0009410
GO:0009612
GO:0009617
GO:0009887
GO:0010033
GO:0010035
GO:0010224
GO:0010468
GO:0010575
GO:0010628
GO:0012501
GO:0014040
GO:0014070
GO:0016525
GO:0019221
GO:0019899
GO:0019901
GO:0023052
GO:0030154
GO:0030163
GO:0031490
GO:0031625
GO:0032495
GO:0032496
GO:0032570
GO:0032731
GO:0032735
GO:0032755
GO:0032757
GO:0032868
GO:0032991
GO:0033209
GO:0033234
GO:0033590
GO:0034097
GO:0034142
GO:0035525
GO:0035556
GO:0035729
GO:0035994
GO:0036211
GO:0038061
GO:0038084
GO:0038161
GO:0042177
GO:0042277
GO:0042301
GO:0042542
GO:0042802
GO:0042803
GO:0042805
GO:0042826
GO:0043066
GO:0043123
GO:0043200
GO:0043226
GO:0043565
GO:0044877
GO:0045087
GO:0045202
GO:0045892
GO:0045893
GO:0045944
GO:0046627
GO:0048856
GO:0050727
GO:0050862
GO:0051059
GO:0051092
GO:0051591
GO:0051607
GO:0070301
GO:0070431
GO:0070498
GO:0070555
GO:0071159
GO:0071222
GO:0071223
GO:0071224
GO:0071316
GO:0071347
GO:0071354
GO:0071356
GO:0071532
GO:0098542
GO:0098978
GO:0099527
GO:0140110
GO:0140296
GO:0140297
GO:1901223
GO:1901224
GO:1902004
GO:1902894
GO:1902895
GO:1904385
GO:1904996
GO:2000630
GO:2001237
HMNXSV003020531
ILMN_1705266
PH_hs_0022492
PH_hs_0035578
TC11001939.hg
TC11003206.hg
TC11003207.hg
U33838_s_at
Z22951_rna1_s_at
g11496238_3p_at
g189503_3p_a_at
p33858
Participates
as a component of
NF-kB p65:p65 [nucleoplasm] (Homo sapiens)
NFKB1(1-433):RELA [nucleoplasm] (Homo sapiens)
NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MeK310-RELA [nucleoplasm]
p-S536-RELA [nucleoplasm]
p-S276,5xAcK-RELA [nucleoplasm]
p-S276-RELA [nucleoplasm]
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
RELA [cytosol]
Inferred To
Dif [nucleoplasm]
(Drosophila melanogaster)
RELA [nucleoplasm]
(Bos taurus)
RELA [nucleoplasm]
(Canis familiaris)
RELA [nucleoplasm]
(Gallus gallus)
RELA [nucleoplasm]
(Sus scrofa)
Homologues of RELA [nucleoplasm]
(Drosophila melanogaster)
Rela [nucleoplasm]
(Mus musculus)
Rela [nucleoplasm]
(Rattus norvegicus)
dl [nucleoplasm]
(Drosophila melanogaster)
rel [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_001230913.1
,
NP_068810.3
,
NP_001138610.1
Guide to Pharmacology - Targets
3280
OpenTargets
ENSG00000173039
ZINC - Substances
TF65_HUMAN
ZINC - Biogenic
TF65_HUMAN
ZINC target
Q04206
PRO
Q04206
PDB
6YPY
,
3RC0
,
7NQP
,
6QHM
,
6YP3
,
7NM3
,
3GUT
,
6YOW
,
4KV1
,
3QXY
,
7O6F
,
7NMH
,
4KV4
,
6YPL
,
7BIY
,
7O3Q
,
7NV4
,
7NZG
,
7NY4
,
7O5U
,
7NLE
,
7O6I
,
7NXS
,
1NFI
,
7BI3
,
7NJ9
,
7O57
,
7O6O
,
7O3R
,
7O5X
,
7NLA
,
7NR7
,
6YP8
,
7LF4
,
5URN
,
2LSP
,
7O34
,
6NV2
,
7NZ6
,
7NYE
,
7BJB
,
6YP2
,
7O3P
,
6YOY
,
7NXW
,
7O5P
,
6YQ2
,
7NZV
,
7O5F
,
7LET
,
7O6K
,
7O5A
,
6QHL
,
7NM1
,
7BJW
,
6YOX
,
7NYF
,
2O61
,
7NJB
,
7NXY
,
7O5S
,
7O5G
,
7O6M
,
7O3A
,
7NYG
,
5U4K
,
7BJL
,
7O5C
,
7BIW
,
7O6G
,
7NK5
,
7O5D
,
7NSV
,
7NZK
,
7O3F
,
7BKH
,
7BJF
,
7NM9
,
7O5O
,
7NXT
,
7NK3
,
7NWS
,
7O6J
,
7LEU
,
7O59
,
7BIQ
,
7O3S
,
7NVI
ZINC - Investigational
TF65_HUMAN
ZINC - Metabolites
TF65_HUMAN
GeneCards
Q04206
HPA
ENSG00000173039-RELA
Ensembl
ENSG00000173039
,
ENSP00000384273
,
ENST00000406246
,
ENST00000308639
,
ENSP00000311508
Pharos - Targets
Q04206
ZINC - Predictions - Purchasable
TF65_HUMAN
Orphanet
22677
Interactors (100)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25963 NFKBIA
9
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.977
27
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.924
16
UniProt:NFKBIA ENSG00000100906
0.905
8
UniProt:Q15653 NFKBIB
3
p-S19,S23-Ub-NFKBIB [cytosol]
(R-HSA-1168571)
p-S19,S23-NFKBIB [cytosol]
(R-HSA-177670)
NFKBIB [cytosol]
(R-HSA-168132)
0.85
9
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.832
9
UniProt:O60885 BRD4
1
BRD4 [nucleoplasm]
(R-HSA-9680425)
0.811
8
UniProt:P23396 RPS3
2
RPS3 [nucleoplasm]
(R-HSA-6798714)
RPS3 [cytosol]
(R-HSA-72369)
0.797
8
UniProt:P19838-PRO_0000030311 NFKB1
0.793
7
IntAct:EBI-1566585 IL8
0.788
9
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-565-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-337-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-185-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-261-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-413-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-109-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-641-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-489-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.77
6
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.757
6
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.755
4
UniProt:Q8WTS6 SETD7
1
SETD7 [nucleoplasm]
(R-HSA-1183221)
0.737
12
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.729
5
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.706
5
UniProt:Q8N668 COMMD1
2
COMMD1 [nucleoplasm]
(R-HSA-8955094)
COMMD1 [cytosol]
(R-HSA-8955110)
0.693
7
UniProt:O95863 SNAI1
1
SNAI1 [nucleoplasm]
(R-HSA-2980903)
0.693
5
UniProt:P14598 NCF1
4
NCF1 [cytosol]
(R-HSA-1222296)
p-6S-NCF1 [phagolysosome]
(R-HSA-1996220)
p-S345-NCF1 [cytosol]
(R-HSA-9626824)
p-6S-NCF1 [cytosol]
(R-HSA-9626854)
0.682
8
UniProt:O15111 CHUK
4
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
p-Y187,Y198-CHUK [cytosol]
(R-HSA-9861501)
0.669
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.659
5
UniProt:Q09472 EP300
5
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.658
4
UniProt:P68400 CSNK2A1
2
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
CSNK2A1 [cytosol]
(R-HSA-201713)
0.656
3
UniProt:Q13568 IRF5
3
p-S446-IRF5 [nucleoplasm]
(R-HSA-9860304)
p-S446-IRF5 [cytosol]
(R-HSA-9860271)
IRF5 [cytosol]
(R-HSA-1015676)
0.656
6
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.656
6
IntAct:EBI-2213855 BIRC3
0.643
3
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.639
5
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.625
4
UniProt:P18847-3 ATF3
0.623
5
UniProt:O00221 NFKBIE
3
NFKBIE [cytosol]
(R-HSA-1168580)
p-S157,S161-NFKBIE [cytosol]
(R-HSA-1168561)
p-S157,S161-Ub-NFKBIE [cytosol]
(R-HSA-1168563)
0.621
3
UniProt:O00255-2 MEN1
0.602
4
UniProt:Q9ESU6 BRD4
0.602
6
UniProt:Q8N6T7 SIRT6
1
SIRT6 [nucleoplasm]
(R-HSA-5685963)
0.602
4
IntAct:EBI-10826665 NKILA
0.599
6
UniProt:Q9BQ69 MACD1
0.599
7
UniProt:Q53EL6 PDCD4
1
PDCD4 [cytosol]
(R-HSA-5432887)
0.599
6
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.592
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.591
6
UniProt:P46695 IER3
1
IER3 [cytosol]
(R-HSA-6811515)
0.591
6
UniProt:Q8X834 Q8X834
0.59
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.589
3
UniProt:P17612 PRKACA
4
PRKACA [mitochondrial matrix]
(R-HSA-9838291)
PRKACA [ciliary base]
(R-HSA-5610402)
PRKACA [nucleoplasm]
(R-HSA-111936)
PRKACA [cytosol]
(R-HSA-57844)
0.581
3
UniProt:Q99612 KLF6
0.576
6
UniProt:Q04206 RELA
7
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S536-RELA [nucleoplasm]
(R-HSA-9861499)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.573
3
UniProt:Q13625 TP53BP2
1
TP53BP2 [nucleoplasm]
(R-HSA-6799780)
0.558
4
UniProt:Q13625-2 TP53BP2
0.557
6
UniProt:P62826 RAN
2
RAN [nucleoplasm]
(R-HSA-165528)
RAN [cytosol]
(R-HSA-165540)
0.556
3
UniProt:O75400-2 PRPF40A
0.556
3
UniProt:O41974 O41974
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:P28329-3 P283293
0.556
3
UniProt:P06307 CCK
1
CCK [extracellular region]
(R-HSA-388539)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.556
3
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.556
5
UniProt:P22736-1 NR4A1
0.544
3
UniProt:Q8VIM5-1 MYOCD
0.544
2
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.544
2
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.543
3
UniProt:O75582 RPS6KA5
3
RPS6KA5 [cytosol]
(R-HSA-772525)
RPS6KA5 [nucleoplasm]
(R-HSA-198657)
p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm]
(R-HSA-198683)
0.536
2
IntAct:EBI-6726290 ICAM1
0.527
3
UniProt:CCL2 ENSG00000108691
0.527
3
UniProt:TNF ENSG00000204490
0.527
3
IntAct:EBI-9873017 BIRC2
0.527
2
UniProt:IL2 ENSG00000109471
0.527
2
IntAct:EBI-1550784 CDKN1A
0.527
2
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.527
2
IntAct:EBI-10052614 ICAM1
0.524
3
UniProt:P0C774 V
0.524
3
UniProt:P10226 PAP
0.524
6
UniProt:Q96JB5 CK5P3
0.524
4
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.524
2
UniProt:Q9NY61 AATF
1
AATF [cytosol]
(R-HSA-205071)
0.524
3
UniProt:P69976 SCTL
0.508
2
UniProt:A0A2U2H0Y9 A0A2U2H0Y9
0.508
2
UniProt:P31491 YERA
0.508
2
UniProt:P53779 MAPK10
3
MAPK10 [cytosol]
(R-HSA-450352)
p-T221,Y223-MAPK10 [cytosol]
(R-HSA-450214)
p-T221,Y223-MAPK10 [nucleoplasm]
(R-HSA-450311)
0.508
2
UniProt:A0A384KL23 A0A384KL23
0.508
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [nucleoplasm]
(R-HSA-165968)
PPP2R1A [cytosol]
(R-HSA-165982)
0.499
2
IntAct:EBI-958860 BCL10
0.499
2
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.499
3
UniProt:B3CRR2 B3CRR2
0.499
3
IntAct:EBI-10021116 CCL5-DERIVED
0.499
3
IntAct:EBI-10021813 CCL5
0.499
4
UniProt:Q96SN8 CDK5RAP2
1
CDK5RAP2 [cytosol]
(R-HSA-380282)
0.499
3
IntAct:EBI-10021565 CCL5-DERIVED
0.499
2
UniProt:B3CTB0 B3CTB0
0.499
2
UniProt:O15294 OGT
2
OGT [nucleoplasm]
(R-HSA-3321845)
OGT [cytosol]
(R-HSA-9687814)
0.499
2
UniProt:Q13148 TADBP
0.463
3
UniProt:Q4KRW3 M21
0.463
2
UniProt:P21980 TGM2
0.463
3
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.463
4
UniProt:P78545 ELF3
2
ELF3 [nucleoplasm]
(R-HSA-9021353)
p-S68-ELF3 [nucleoplasm]
(R-HSA-9021349)
0.463
2
UniProt:O75531 BANF1
4
p-T2,T3,S4-BANF1 [nucleoplasm]
(R-HSA-2993896)
BANF1 [nucleoplasm]
(R-HSA-175030)
BANF1 [cytosol]
(R-HSA-175371)
p-T2,T3,S4-BANF1 [cytosol]
(R-HSA-2995375)
0.463
3
UniProt:Q92784-2 DPF3
0.462
3
UniProt:Q92784-1 DPF3
0.462
3
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.462
2
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