Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6

Stable Identifier
R-HSA-177694
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
cytosol, endosome membrane
ReviewStatus
5/5
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Viral dsRNA:TLR3:TICAM1 complex recruits TRAF6
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TRAF6 is recruited to the N-terminal domain of TICAM1 and this event is followed by auto polyubiquitination and oligomerization of TRAF6.
Literature References
PubMed ID Title Journal Year
20047764 Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway

Matsumoto, M, Hatakeyama, S, Oshiumi, H, Funami, K, Seya, T, Sasai, M, Tatematsu, M

Mol Immunol 2010
11057907 Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

Deng, L, Pickart, C, Spencer, E, You, J, Wang, C, Slaughter, C, Braun, A, Chen, ZJ, Yang, L

Cell 2000
19112497 TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL

Walsh, MC, Molnar, EE, Maurizio, PL, Choi, Y, Kim, GK

PLoS One 2008
Participants
Input
Output
Participates
as an event of
Orthologous Events
viral dsRNA: TLR3: TICAM1 recruits TRAF6 (Gallus gallus)
Authored
Shamovsky, V  (2009-12-16)
Reviewed
Fitzgerald, KA  (2012-11-13)
Created
Gillespie, ME  (2006-04-04)
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