EGFR dimerization

Stable Identifier
R-HSA-177922
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

EGF and other growth factors induce oligomerization of their specific receptors. Inactive EGFR monomers are in equilibrium with active EGFR dimers and binding of the EGF ligand stabilizes the active dimeric form.

Literature References
PubMed ID Title Journal Year
8639530 Activation of epidermal growth factor receptor by epidermal growth factor

Sherrill, JM, Kyte, J

Biochemistry 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created