Dephosphorylation of Gab1 by SHP2

Stable Identifier
R-HSA-177924
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Dephosphorylation of Gab1 by SHP2
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Phosphorylated GAB1 can bind PI3 kinase by its regulatory alpha subunit. SHP2 dephosphorylation of the tyrosine residues 447, 472 and 589 on GAB1 means PI3 kinase can no longer bind to the complex in the plasma membrane and cannot be activated.
Literature References
PubMed ID Title Journal Year
10734310 Sustained recruitment of phospholipase C-gamma to Gab1 is required for HGF-induced branching tubulogenesis

Williams, TA, Gual, P, Giordano, S, Rocchi, S, Comoglio, PM, Van Obberghen, E

Oncogene 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

non-membrane spanning protein tyrosine phosphatase activity of EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:SHP2 [plasma membrane] (Homo sapiens)
Activity
non-membrane spanning protein tyrosine phosphatase activity (GO:0004726)
Orthologous Events
Dephosphorylation of Gab1 by SHP2 (Bos taurus)
Dephosphorylation of Gab1 by SHP2 (Canis familiaris)
Dephosphorylation of Gab1 by SHP2 (Drosophila melanogaster)
Dephosphorylation of Gab1 by SHP2 (Gallus gallus)
Dephosphorylation of Gab1 by SHP2 (Mus musculus)
Dephosphorylation of Gab1 by SHP2 (Rattus norvegicus)
Dephosphorylation of Gab1 by SHP2 (Sus scrofa)
Dephosphorylation of Gab1 by SHP2 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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