Binding of PIK3 regulatory alpha subunit to GRB2:GAB1

Stable Identifier
R-HSA-177931
Type
Reaction
Species
Homo sapiens
Compartment
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The Src homology 2 (SH2) domain of the phosphatidylinositol 3-kinase (PIK3) regulatory subunit (PIK3R1, i.e. PI3Kp85) binds to GAB1 in a phosphorylation-independent manner. GAB1 serves as a docking protein which recruits a number of downstream signalling proteins. PIK3R1 can bind to either GAB1 or phosphorylated GAB1.

Literature References
PubMed ID Title Journal Year
11606067 Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein

Onishi-Haraikawa, Y, Funaki, M, Gotoh, N, Shibuya, M, Inukai, K, Katagiri, H, Fukushima, Y, Anai, M, Ogihara, T, Sakoda, H, Ono, H, Kikuchi, M, Oka, Y, Asano, T

Biochem Biophys Res Commun 2001
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