EGFR binds EGF ligand

Stable Identifier
R-HSA-177942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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EGFR binds EGF ligand
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The prototypic receptor tyrosine kinase (RTK) EGFR is composed of 3 major domains; an extracellular domain linked via a single membrane-spanning domain to a cytoplasmic domain. EGF binds to the extracellular domain from where the signal is transmitted to the cytoplasmic domain.

Literature References
PubMed ID Title Journal Year
8639530 Activation of epidermal growth factor receptor by epidermal growth factor

Sherrill, JM, Kyte, J

Biochemistry 1996
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Negatively by
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Authored
Castagnoli, L  (2006-10-10)
Reviewed
Muthuswamy, S  (2007-02-16)
Created
Jassal, B  (2006-04-11)