Activation of SHP2 through the binding to phospho-Gab1

Stable Identifier
R-HSA-177944
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activation of SHP2 through the binding to phospho-Gab1
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The SH2 domains repress phosphatase activity of SHP2. Binding of these domains to phosphotyrosine-containing proteins relieves this autoinhibition, possibly by inducing a conformational change in the enzyme.
Literature References
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Orthologous Events
Activation of SHP2 through the binding to phospho-Gab1 (Bos taurus)
Activation of SHP2 through the binding to phospho-Gab1 (Canis familiaris)
Activation of SHP2 through the binding to phospho-Gab1 (Gallus gallus)
Activation of SHP2 through the binding to phospho-Gab1 (Mus musculus)
Activation of SHP2 through the binding to phospho-Gab1 (Rattus norvegicus)
Activation of SHP2 through the binding to phospho-Gab1 (Sus scrofa)
Activation of SHP2 through the binding to phospho-Gab1 (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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