Reactome | SMURF2 [nucleoplasm]

SMURF2 [nucleoplasm]

Stable Identifier

R-HSA-178202

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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External Reference Information

External Reference

UniProt:Q9HAU4 SMURF2

Gene Names

SMURF2

Chain

chain:1-748

Reference Genes

BioGPS Gene:64750 SMURF2

COSMIC (genes):SMURF2 SMURF2

CTD Gene:64750 SMURF2

dbSNP Gene:64750 SMURF2

ENSEMBL:ENSG00000108854 SMURF2

HGNC:16809 SMURF2

KEGG:hsa:64750 SMURF2

Monarch:64750 SMURF2

NCBI Gene:64750 SMURF2

OMIM:605532 SMURF2

UCSC:Q9HAU4 SMURF2

Reference Transcript

RefSeq:NM_022739.3 SMURF2

Other Identifiers

11723820_a_at

11723821_a_at

11748382_a_at

16847841

17121634

205596_PM_s_at

205596_s_at

227489_PM_at

227489_at

232020_3p_at

232020_PM_at

232020_at

33354_at

3717021

3732647

3766961

3766962

3766963

3766965

3766968

3766972

3766973

3766974

3766975

3766976

3766977

3766979

3766983

3766986

3766989

3766991

3766997

3766999

3767000

3767001

3767002

3767003

3767006

3767008

3767026

3767027

3767028

4040313

4040318

4040626

4040630

58405_at

64750

65451_i_at

8017651

91240_at

A_21_P0011536

A_23_P100754

A_24_P210888

A_33_P3370751

GE82713

GE88328

GO:0000122

GO:0000151

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006511

GO:0016567

GO:0016607

GO:0016740

GO:0017015

GO:0030163

GO:0030512

GO:0030514

GO:0042802

GO:0043161

GO:0043226

GO:0045121

GO:0045892

GO:0046332

GO:0060071

GO:0061630

GO:0090263

GO:0140096

GO:1901165

HMNXSV003009869

Hs.169872.0.A1_3p_at

Hs.323849.0.S1_3p_x_at

ILMN_1675429

PH_hs_0025712

TC17001803.hg

g12408118_3p_at

Participates

as a member of

SMURF [nucleoplasm] (Homo sapiens)

as a component of

as an input of

as an output of

SMURF2 monoubiquitinates SMAD3 (Homo sapiens)

as a candidate of

RNF111/SMURF2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

SMURF2 [cytosol]

Inferred To

SMURF2 [nucleoplasm] (Bos taurus)

SMURF2 [nucleoplasm] (Canis familiaris)

SMURF2 [nucleoplasm] (Gallus gallus)

SMURF2 [nucleoplasm] (Sus scrofa)

Smurf2 [nucleoplasm] (Mus musculus)

Smurf2 [nucleoplasm] (Rattus norvegicus)

Smurf [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SMURF2 [nucleoplasm] (Caenorhabditis elegans)

smurf2 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_073576.1

OpenTargets

ENSG00000108854

ENSEMBL

ENST00000262435, ENSP00000262435

HPA

ENSG00000108854-SMURF2

PRO

Q9HAU4

Pharos - Targets

Q9HAU4

GlyGen

Q9HAU4

PDB

7M3Q, 6FX4, 2KXQ, 2DJY, 2JQZ, 2LTZ, 1ZVD

HMDB Protein

HMDBP09306

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15797 SMAD1	4	p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) SMAD1 [cytosol] (R-HSA-201468) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.855	7
UniProt:Q15796 SMAD2	20	Ub-SMAD2 [cytosol] (R-HSA-6782774) p-S465,S467-SMAD2 P305L [cytosol] (R-HSA-3315471) p-S465,S467-SMAD2 D300A [cytosol] (R-HSA-3315064) p-S465,S467-SMAD2 D300N [cytosol] (R-HSA-3315066) p-S465,S467-SMAD2 A354T [cytosol] (R-HSA-3315474) p-S465,S467-SMAD2 P305Q [cytosol] (R-HSA-3315070) p-S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009185) p-S465,S467-SMAD2 [cytosol] (R-HSA-3009186) SMAD2 [cytosol] (R-HSA-3006353) p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-3009189) Ub,p-T220,S465,S467-SMAD2 [nucleoplasm] (R-HSA-9773843) SMAD2 [nucleoplasm] (R-HSA-3006352) p-S250-SMAD2 [cytosol] (R-HSA-9731121) SMAD2 Q429* [cytosol] (R-HSA-9668727) SMAD2 S467P [cytosol] (R-HSA-3304375) SMAD2 L315* [cytosol] (R-HSA-9668725) SMAD2 E439* [cytosol] (R-HSA-9668724) SMAD2 Q455* [cytosol] (R-HSA-9668731) SMAD2 S306* [cytosol] (R-HSA-9668730) SMAD2 S296* [cytosol] (R-HSA-9668729)	0.811	6
UniProt:O15105 SMAD7	2	SMAD7 [nucleoplasm] (R-HSA-178197) SMAD7 [cytosol] (R-HSA-173478)	0.801	7
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.799	8
UniProt:Q9Y3C5 RNF11			0.737	5
UniProt:Q9HAU4 SMURF2	2	SMURF2 [nucleoplasm] (R-HSA-178202) SMURF2 [cytosol] (R-HSA-173537)	0.709	6
UniProt:Q99717 SMAD5	3	SMAD5 [cytosol] (R-HSA-201431) p-S463,S465-SMAD5 [nucleoplasm] (R-HSA-201432) p-S463,S465-SMAD5 [cytosol] (R-HSA-201473)	0.659	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.623	4
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.602	3
UniProt:P46934-4 NEDD4			0.59	2
UniProt:Q15038 DAZP2			0.573	2
UniProt:Q8WWV3 RT4I1			0.556	3
UniProt:Q13017 ARHGAP5	1	ARHGAP5 [cytosol] (R-HSA-195084)	0.547	2
UniProt:Q9NWM3 CUED1			0.547	2
UniProt:Q96GW9 MARS2	1	MARS2 [mitochondrial matrix] (R-HSA-379555)	0.527	2
UniProt:Q02383 SEMG2			0.527	2
UniProt:Q7L985 LIGO2			0.527	2
UniProt:Q9WMX2-PRO_0000037548			0.508	2

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