SMAD7:SMURF1 complex is exported to the cytosol

Stable Identifier
R-HSA-178215
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

After SMAD7:SMURF1 complex binds to XPO1 (CRM1) through the nuclear export signal (NES) in the C-terminus of SMURF1, XPO1 enables transport of SMAD7:SMURF1 to the cytosol (Suzuki et al. 2002, Tajima et al. 2003). A recombinant mouse Smad7 and recombinant human SMURF1 were used in these experiments.

Literature References
PubMed ID Title Journal Year
12151385 Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

Suzuki, C, Murakami, G, Fukuchi, M, Shimanuki, T, Shikauchi, Y, Imamura, T, Miyazono, K

J Biol Chem 2002
12519765 Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

Tajima, Y, Goto, K, Yoshida, M, Shinomiya, K, Sekimoto, T, Yoneda, Y, Miyazono, K, Imamura, T

J Biol Chem 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transporter activity of SMAD7:SMURF1:XPO1 [nucleoplasm]
Physical Entity
Activity
Inferred From
Authored
Reviewed