Chondroitin sulfate/dermatan sulfate metabolism

Stable Identifier
R-HSA-1793185
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
Click the image above or here to open this pathway in the Pathway Browser

Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). The chains are usually attached to proteins forming a proteoglycan. CS is an important structural component of cartilage due to it's ability to withstand compression. It is also a widely used dietary supplement for osteoarthritis. When some of the GlcA residues are epimerized into L-iduronic acid (IdoA) the resulting disaccharide is then referred to as dermatan sulfate (DS) (Silbert & Sugumaran 2002). DS is the most predominant GAG in skin but is also found in blood vessels, heart valves, tendons, and the lungs. It may play roles in cardiovascular disease, tumorigenesis, infection, wound repair and fibrosis (Trowbridge & Gallo 2002).

Literature References
PubMed ID Title Journal Year
12512856 Biosynthesis of chondroitin/dermatan sulfate

Silbert, JE, Sugumaran, G

IUBMB Life 2002
17239764 Biosynthesis of chondroitin sulfate: from the early, precursor discoveries to nowadays, genetics approaches

Pavão, MS, Vilela-Silva, AC, Mourão, PA

Adv Pharmacol 2006
12213784 Dermatan sulfate: new functions from an old glycosaminoglycan

Trowbridge, JM, Gallo, RL

Glycobiology 2002
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created