APC-Cdc20 mediated degradation of Nek2A

Stable Identifier
R-HSA-179409
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
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APC-Cdc20 mediated degradation of Nek2A
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Like Cyclin A, NIMA-related kinase 2A (Nek2A) is degraded during pro-metaphase in a checkpoint-independent manner.

Literature References
PubMed ID Title Journal Year
16648845 Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Hayes, MJ, Kimata, Y, Wattam, SL, Lindon, C, Mao, G, Yamano, H, Fry, AM

Nat Cell Biol 2006
11742988 APC/C-mediated destruction of the centrosomal kinase Nek2A occurs in early mitosis and depends upon a cyclin A-type D-box

Hames, RS, Wattam, SL, Yamano, H, Bacchieri, R, Fry, AM

EMBO J 2001
Participants
Events
Participant Of
hasEvent
Event Information
Go Biological Process
regulation of exit from mitosis (0007096)
Orthologous Events
APC-Cdc20 mediated degradation of Nek2A (Canis familiaris)
APC-Cdc20 mediated degradation of Nek2A (Danio rerio)
APC-Cdc20 mediated degradation of Nek2A (Dictyostelium discoideum)
APC-Cdc20 mediated degradation of Nek2A (Drosophila melanogaster)
APC-Cdc20 mediated degradation of Nek2A (Gallus gallus)
APC-Cdc20 mediated degradation of Nek2A (Mus musculus)
APC-Cdc20 mediated degradation of Nek2A (Rattus norvegicus)
APC-Cdc20 mediated degradation of Nek2A (Sus scrofa)
APC-Cdc20 mediated degradation of Nek2A (Xenopus tropicalis)
Cross References
BioModels Database
Authored
Lorca, T  (2006-01-26)
Castro, A  (2006-01-26)
Reviewed
Peters, JM  (2006-03-28)
Created
Matthews, L  (2006-04-28)
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